KEGG   ENZYME: 1.1.1.316Help
Entry
EC 1.1.1.316                Enzyme                                 

Name
L-galactose 1-dehydrogenase;
L-GalDH;
L-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+ [RN:R07675]
Reaction(KEGG)
Substrate
L-galactose [CPD:C01825];
NAD+ [CPD:C00003]
Product
L-galactono-1,4-lactone [CPD:C01115];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step in the ascorbate biosynthesis in higher plants (Smirnoff-Wheeler pathway). The activity with NADP+ is less than 10% of the activity with NAD+.
History
EC 1.1.1.316 created 2011
Pathway
Ascorbate and aldarate metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K17744  
L-galactose dehydrogenase
Genes
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0001s29390g(POPTRDRAFT_815719) POPTR_0009s08490g(POPTRDRAFT_833135)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os12t0482700-01(Os12g0482700)
OBR: 
BDI: 
SBI: 
SORBI_08g014630(SORBIDRAFT_08g014630)
ZMA: 
732776(pco064579)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
PGR: 
DFA: 
DFA_04455(alrE)
SPAR: 
CCZ: 
VBA: 
PHM: 
 » show all
Taxonomy
Reference
1  [PMID:15509850]
  Authors
Mieda T, Yabuta Y, Rapolu M, Motoki T, Takeda T, Yoshimura K, Ishikawa T, Shigeoka S
  Title
Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate.
  Journal
Plant. Cell. Physiol. 45 (2004) 1271-9.
  Sequence
Reference
2  [PMID:12047629]
  Authors
Gatzek S, Wheeler GL, Smirnoff N
  Title
Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis.
  Journal
Plant. J. 30 (2002) 541-53.
  Sequence
[ath:AT4G33670]
Reference
3  [PMID:9620799]
  Authors
Wheeler GL, Jones MA, Smirnoff N
  Title
The biosynthetic pathway of vitamin C in higher plants.
  Journal
Nature. 393 (1998) 365-9.
Reference
4  [PMID:19297184]
  Authors
Oh MM, Carey EE, Rajashekar CB
  Title
Environmental stresses induce health-promoting phytochemicals in lettuce.
  Journal
Plant. Physiol. Biochem. 47 (2009) 578-83.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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