KEGG   ENZYME: 1.1.1.325Help
Entry
EC 1.1.1.325                Enzyme                                 

Name
sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-threo-7,8-dihydrobiopterin:NADP+ oxidoreductase
Reaction(IUBMB)
(1) L-threo-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ [RN:R09989];
(2) L-threo-tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H+ [RN:R09990]
Reaction(KEGG)
Substrate
L-threo-7,8-dihydrobiopterin [CPD:C20263];
NADP+ [CPD:C00006];
L-threo-tetrahydrobiopterin [CPD:C20264]
Product
sepiapterin [CPD:C00835];
NADPH [CPD:C00005];
H+ [CPD:C00080];
6-pyruvoyl-5,6,7,8-tetrahydropterin [CPD:C03684]
Comment
This enzyme, isolated from the bacterium Chlorobium tepidum, catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP. cf. EC 1.1.1.153, sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
History
EC 1.1.1.325 created 2012
Orthology
K17745  
sepiapterin reductase
Genes
CTE: 
CPC: 
CCH: 
CPH: 
CPB: 
CLI: 
PVI: 
PLT: 
PPH: 
PAA: 
CTS: 
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Taxonomy
Reference
1  [PMID:10333495]
  Authors
Cho SH, Na JU, Youn H, Hwang CS, Lee CH, Kang SO
  Title
Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum.
  Journal
Biochem. J. 340 ( Pt 2) (1999) 497-503.
  Sequence
[cte:CT0609]
Reference
2  [PMID:16510994]
  Authors
Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH.
  Title
Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum.
  Journal
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 61 (2005) 202-4.
  Sequence
[cte:CT0609]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9059-48-7

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