KEGG   ENZYME: 1.1.1.329Help
Entry
EC 1.1.1.329                Enzyme                                 

Name
2-deoxy-scyllo-inosamine dehydrogenase;
neoA (gene name);
kanK (gene name, ambiguous);
kanE (gene name, ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-deoxy-scyllo-inosamine:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
2-deoxy-scyllo-inosamine + NAD(P)+ = 3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+ [RN:R08892 R10130]
Reaction(KEGG)
Substrate
2-deoxy-scyllo-inosamine [CPD:C17580];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-amino-2,3-dideoxy-scyllo-inosose [CPD:C17581];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Requires zinc. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, neomycin and ribostamycin. cf. EC 1.1.99.38, 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent).
History
EC 1.1.1.329 created 2012
Pathway
Neomycin, kanamycin and gentamicin biosynthesis
Biosynthesis of antibiotics
Orthology
K13548  
2-deoxy-scyllo-inosamine dehydrogenase
Reference
1  [PMID:16506694]
  Authors
Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K.
  Title
Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773.
  Journal
J. Antibiot. (Tokyo). 58 (2005) 766-74.
  Sequence
Reference
2  [PMID:19466609]
  Authors
Nepal KK, Oh TJ, Sohng JK
  Title
Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853.
  Journal
Mol. Cells. 27 (2009) 601-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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