KEGG   ENZYME: 1.1.1.33Help
Entry
EC 1.1.1.33                 Enzyme                                 

Name
mevaldate reductase (NADPH);
mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase;
mevaldate reductase (NADPH)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-mevalonate:NADP+ oxidoreductase
Reaction(IUBMB)
(R)-mevalonate + NADP+ = mevaldate + NADPH + H+ [RN:R02247]
Reaction(KEGG)
Substrate
(R)-mevalonate [CPD:C00418];
NADP+ [CPD:C00006]
Product
mevaldate [CPD:C00772];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)].
History
EC 1.1.1.33 created 1961
Reference
1
  Authors
Coon, M.J., Kupiecki, F.P., Dekker, E.E., Schlesinger, M.J. and del Campillo, A.
  Title
The enzymic synthesis of branched-chain acids.
  Journal
In: Wolstenholme, G.E.W. and O'Connor, M. (Eds.), CIBA Symposium on the Biosynthesis of Terpenes and Sterols, CIBA Symposium on the Biosynthesis of Terpenes and Sterols, London, 1959, p. 62-74.
Reference
2
  Authors
von Wartburg, J.P. and Wermoth, B.
  Title
Aldehyde reductase.
  Journal
In: Jakoby, W.B. (Ed.), Enzymatic Basis of Detoxication, vol. 1, Academic Press, New York, 1980, p. 249-260.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-34-6

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