KEGG   ENZYME: 1.1.1.330Help
Entry
EC 1.1.1.330                Enzyme                                 

Name
very-long-chain 3-oxoacyl-CoA reductase;
very-long-chain 3-ketoacyl-CoA reductase;
very-long-chain beta-ketoacyl-CoA reductase;
KCR (gene name);
IFA38 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(3R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase
Reaction(IUBMB)
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + NADPH + H+ [RN:R10826]
Reaction(KEGG)
R10826;
(other) R07759
Show
Substrate
very-long-chain (3R)-3-hydroxyacyl-CoA [CPD:C20878];
NADP+ [CPD:C00006]
Product
very-long-chain 3-oxoacyl-CoA [CPD:C20877];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The second component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. The enzyme is active with substrates with chain length of C16 to C34, depending on the species. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase, and EC 1.3.1.93, very-long-chain enoyl-CoA reductase.
History
EC 1.1.1.330 created 2012
Pathway
Fatty acid elongation
Biosynthesis of unsaturated fatty acids
Biosynthesis of secondary metabolites
Orthology
K10251  
17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Genes
HSA: 
51144(HSD17B12)
PTR: 
741010(HSD17B12)
PPS: 
100971612(HSD17B12)
GGO: 
101126579(HSD17B12)
PON: 
100439025(HSD17B12)
NLE: 
100600308(HSD17B12)
MCC: 
106993263(HSD17B12)
MCF: 
101867269(HSD17B12)
RRO: 
104673891(HSD17B12)
CJC: 
100399351(HSD17B12)
MMU: 
56348(Hsd17b12)
RNO: 
84013(Hsd17b12)
CGE: 
100751291(Hsd17b12)
NGI: 
103746669(Hsd17b12)
HGL: 
101717552(Hsd17b12)
OCU: 
TUP: 
102495234(HSD17B12)
CFA: 
475939(HSD17B12)
AML: 
100484147(HSD17B12)
UMR: 
103672348(HSD17B12)
FCA: 
101082595(HSD17B12)
PTG: 
102963001(HSD17B12)
BTA: 
789567(HSD17B12)
BOM: 
PHD: 
CHX: 
OAS: 
101110086(HSD17B12) 101112590(hsd20b2)
SSC: 
100312972(HSD17B12)
CFR: 
102515430(HSD17B12)
BACU: 
102998439(HSD17B12)
LVE: 
103068441(HSD17B12)
ECB: 
100050075(HSD17B12)
MYB: 
102263627(HSD17B12)
MYD: 
102766960(HSD17B12)
PALE: 
102889386(HSD17B12)
MDO: 
100013277(HSD17B12)
SHR: 
100917982(HSD17B12)
OAA: 
100079057(HSD17B12)
GGA: 
769787(HSD17B12)
MGP: 
104911119(HSD17B12)
CJO: 
107314810(HSD17B12)
APLA: 
101803586(HSD17B12)
TGU: 
100223843(HSD17B12)
GFR: 
102039695(HSD17B12)
FAB: 
101807632(HSD17B12)
PHI: 
102106801(HSD17B12)
CCW: 
104688088(HSD17B12)
FPG: 
101917180(HSD17B12)
FCH: 
102056639(HSD17B12)
CLV: 
102085015(HSD17B12)
AAM: 
106498375(HSD17B12)
ASN: 
AMJ: 
102559362(HSD17B12)
PSS: 
CMY: 
ACS: 
PBI: 
103049647(HSD17B12)
GJA: 
XLA: 
379747(hsd17b12-b) 495218(hsd17b12-a)
XTR: 
549988(hsd17b12)
DRE: 
322626(hsd17b12b) 327417(hsd17b12a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362094(HSD17B12)
CMK: 
103174968(hsd17b12)
BFO: 
CIN: 
445663(17-beta-HSD)
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD16868(Dsim_GD16868)
DWI: 
DYA: 
Dyak_GE15745(dyak_GLEANR_17230)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
102655714 725258(GB10228)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
CEL: 
CELE_C06B3.4(stdh-1) CELE_C56G2.6(let-767) CELE_F11A5.12(stdh-2)
CBR: 
CBG11441 CBG19695(Cbr-let-767)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G67730(KCR1)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0008s18190g(POPTRDRAFT_565101) POPTR_0010s06220g(POPTRDRAFT_821856) POPTR_0010s06230g(POPTRDRAFT_769035) POPTR_0010s06240g(POPTRDRAFT_565949)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os04t0483500-01(Os04g0483500) Os06t0298700-00(Os06g0298700) Os06t0299200-00(Os06g0299200) Os06t0299300-01(Os06g0299300)
OBR: 
BDI: 
SBI: 
SORBI_01g035200(SORBIDRAFT_01g035200) SORBI_01g047620(SORBIDRAFT_01g047620) SORBI_04g025020(SORBIDRAFT_04g025020) SORBI_06g020580(SORBIDRAFT_06g020580) SORBI_06g020600(SORBIDRAFT_06g020600) SORBI_10g010930(SORBIDRAFT_10g010930) SORBI_10g010960(SORBIDRAFT_10g010960) SORBI_10g010990(SORBIDRAFT_10g010990) SORBI_10g011020(SORBIDRAFT_10g011020)
ZMA: 
103634953(GRMZM2G090733) 103638302(GRMZM2G465868) 103653730(gl8b) 542359(gl8)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CSL: 
CVR: 
APRO: 
CME: 
GSL: 
CCP: 
SCE: 
YBR159W(IFA38)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B02360(NCAS0B02360)
NDI: 
NDAI_0C05330(NDAI0C05330)
TPF: 
TPHA_0L01460(TPHA0L01460)
TBL: 
TBLA_0H03430(TBLA0H03430)
TDL: 
TDEL_0B01260(TDEL0B01260)
KAF: 
KAFR_0E03020(KAFR0E03020)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NTE: 
NEUTE1DRAFT79325(NEUTE1DRAFT_79325)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_900014(AO090026000492)
ANG: 
ANI_1_488024(An02g03570)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT112492(AGABI1DRAFT_112492)
ABV: 
AGABI2DRAFT192460(AGABI2DRAFT_192460)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
ERO: 
NCE: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_165070(127.t00009)
EDI: 
EIV: 
PCB: 
PBE: 
PCY: 
TGO: 
TET: 
PTM: 
PTI: 
TPS: 
AAF: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
GLA: 
BCEN: 
BMK: 
 » show all
Taxonomy
Reference
1  [PMID:11792704]
  Authors
Beaudoin F, Gable K, Sayanova O, Dunn T, Napier JA
  Title
A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase.
  Journal
J. Biol. Chem. 277 (2002) 11481-8.
  Sequence
[sce:YBR159W]
Reference
2  [PMID:12087109]
  Authors
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM
  Title
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
  Journal
J. Biol. Chem. 277 (2002) 35440-9.
  Sequence
[sce:YBR159W]
Reference
3  [PMID:19439572]
  Authors
Beaudoin F, Wu X, Li F, Haslam RP, Markham JE, Zheng H, Napier JA, Kunst L
  Title
Functional characterization of the Arabidopsis beta-ketoacyl-coenzyme A reductase candidates of the fatty acid elongase.
  Journal
Plant. Physiol. 150 (2009) 1174-91.
  Sequence
[ath:AT1G67730]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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