KEGG   ENZYME: 1.1.1.331Help
Entry
EC 1.1.1.331                Enzyme                                 

Name
secoisolariciresinol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(-)-secoisolariciresinol:NAD+ oxidoreductase
Reaction(IUBMB)
(-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 NADH + 2 H+ [RN:R10129]
Reaction(KEGG)
Substrate
(-)-secoisolariciresinol [CPD:C18167];
NAD+ [CPD:C00003]
Product
(-)-matairesinol [CPD:C10682];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Isolated from the plants Forsythia intermedia [1] and Podophyllum peltatum [1-3]. An intermediate lactol is detected in vitro.
History
EC 1.1.1.331 created 2012
Orthology
K19650  
secoisolariciresinol dehydrogenase
Reference
1  [PMID:11278426]
  Authors
Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection.
  Journal
J. Biol. Chem. 276 (2001) 12614-23.
  Sequence
Reference
2  [PMID:15653677]
  Authors
Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C
  Title
Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans.
  Journal
J. Biol. Chem. 280 (2005) 12917-26.
  Sequence
Reference
3  [PMID:16493463]
  Authors
Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG
  Title
Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum.
  Journal
Org. Biomol. Chem. 4 (2006) 808-16.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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