KEGG   ENZYME: 1.1.1.332Help
Entry
EC 1.1.1.332                Enzyme                                 

Name
chanoclavine-I dehydrogenase;
easD (gene name);
fgaDH (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
chanoclavine-I:NAD+ oxidoreductase
Reaction(IUBMB)
chanoclavine-I + NAD+ = chanoclavine-I aldehyde + NADH + H+ [RN:R10128]
Reaction(KEGG)
Substrate
chanoclavine-I [CPD:C09131];
NAD+ [CPD:C00003]
Product
chanoclavine-I aldehyde [CPD:C20379];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.
History
EC 1.1.1.332 created 2012
Orthology
K17746  
chanoclavine-I dehydrogenase
Genes
MGR: 
NHE: 
MAW: 
MAJ: 
AFM: 
ABE: 
TVE: 
Taxonomy
Reference
1  [PMID:20039019]
  Authors
Wallwey C, Matuschek M, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
  Journal
Arch. Microbiol. 192 (2010) 127-34.
  Sequence
Reference
2  [PMID:22403186]
  Authors
Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM
  Title
Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.
  Journal
Microbiology. 158 (2012) 1634-44.
  Sequence
[abe:ARB_04646]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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