KEGG   ENZYME: 1.1.1.337Help
Entry
EC 1.1.1.337                Enzyme                                 

Name
L-2-hydroxycarboxylate dehydrogenase (NAD+);
(R)-sulfolactate:NAD+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
L-2-hydroxyacid dehydrogenase (NAD+);
ComC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase
Reaction(IUBMB)
a (2S)-2-hydroxycarboxylate + NAD+ = a 2-oxocarboxylate + NADH + H+ [RN:R10189]
Reaction(KEGG)
Substrate
(2S)-2-hydroxycarboxylate [CPD:C15565];
NAD+ [CPD:C00003]
Product
2-oxocarboxylate [CPD:C00161];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate [3]. Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
History
EC 1.1.1.337 created 2012
Pathway
Methane metabolism
Orthology
K05884  
L-2-hydroxycarboxylate dehydrogenase (NAD+)
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMP1133(comC)
MMX: 
MMZ: 
MMD: 
MAE: 
MVN: 
MVO: 
MOK: 
MTH: 
MMG: 
MST: 
Msp_0279(comC)
MSI: 
MRU: 
mru_1980(comC)
MEB: 
Abm4_1552(comC)
MEL: 
MEW: 
METH: 
MFV: 
MKA: 
MK0392(comC)
 » show all
Taxonomy
Reference
1  [PMID:10850983]
  Authors
Graupner M, Xu H, White RH.
  Title
Identification of an archaeal 2-hydroxy acid dehydrogenase catalyzing reactions involved in coenzyme biosynthesis in methanoarchaea.
  Journal
J. Bacteriol. 182 (2000) 3688-92.
  Sequence
[mja:MJ_1425]
Reference
2  [PMID:11451450]
  Authors
Graupner M, White RH.
  Title
The first examples of (S)-2-hydroxyacid dehydrogenases catalyzing the transfer of the pro-4S hydrogen of NADH are found in the archaea.
  Journal
Biochim. Biophys. Acta. 1548 (2001) 169-73.
  Sequence
[mja:MJ_1425]
Reference
3  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat. Prod. Rep. 19 (2002) 133-47.
Reference
4  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM.
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology. 151 (2005) 737-47.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
81210-65-3

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