KEGG   ENZYME: 1.1.1.338Help
Entry
EC 1.1.1.338                Enzyme                                 

Name
(2R)-3-sulfolactate dehydrogenase (NADP+);
(R)-sulfolactate:NADP+ oxidoreductase;
L-sulfolactate dehydrogenase;
(R)-sulfolactate dehydrogenase;
ComC
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2R)-3-sulfolactate:NADP+ oxidoreductase
Reaction(IUBMB)
(2R)-3-sulfolactate + NADP+ = 3-sulfopyruvate + NADPH + H+ [RN:R07137]
Reaction(KEGG)
Substrate
(2R)-3-sulfolactate [CPD:C11537];
NADP+ [CPD:C00006]
Product
3-sulfopyruvate [CPD:C05528];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Chromohalobacter salexigens can only utilize NADP+. It functions both biosynthetically in coenzyme M biosynthesis and degradatively, in the degradation of sulfolactate. It can not use (S)-malate and (S)-lactate.
History
EC 1.1.1.338 created 2012
Pathway
Cysteine and methionine metabolism
Microbial metabolism in diverse environments
Orthology
K16844  
(2R)-3-sulfolactate dehydrogenase (NADP+)
Genes
SSAL: 
CSA: 
TSN: 
RPJ: 
REU: 
CTI: 
CBW: 
CGD: 
CR3_0184(comC)
BGE: 
BYI: 
BUO: 
BUE: 
BFN: 
BCAI: 
PDQ: 
PTX: 
PNR: 
BPA: 
BPAR: 
BBR: 
BBM: 
BBH: 
BBX: 
BPT: 
BHO: 
BHM: 
BHZ: 
AXY: 
AXO: 
AXN: 
AXS: 
ADT: 
AKA: 
AMIM: 
VEI: 
VAP: 
VPD: 
LIH: 
HAR: 
RGE: 
BPRC: 
DVM: 
MLO: 
MCI: 
MOP: 
MAM: 
AAK: 
SME: 
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
SMER: 
SMD: 
SFH: 
SFD: 
ATU: 
ARA: 
ATF: 
ATA: 
AGR: 
RTR: 
RIR: 
RHL: 
RGA: 
NGL: 
NGG: 
SHZ: 
OCA: 
OCG: 
OCO: 
BOP: 
AZC: 
MRD: 
MNO: 
RVA: 
FIL: 
FIY: 
RHZ: 
MEY: 
SIL: 
SPO3187(comC)
SIT: 
JAN: 
RDE: 
RLI: 
DSH: 
PSF: 
PGA: 
PGL: 
PGD: 
OAT: 
OAR: 
OTM: 
OSB_22100(comC)
LMD: 
RED: 
PTP: 
MALG: 
RSU: 
PPHR: 
RCE: 
TXI: 
PGV: 
APC: 
CGY: 
RHA: 
SATK: 
MRB: 
MRE: 
MSV: 
 » show all
Taxonomy
Reference
1  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology. 156 (2010) 967-74.
  Sequence
[csa:Csal_1771]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
81210-65-3

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