KEGG   ENZYME: 1.1.1.339Help
Entry
EC 1.1.1.339                Enzyme                                 

Name
dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+);
tll (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase
Reaction(IUBMB)
dTDP-6-deoxy-beta-L-talose + NAD+ = dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ [RN:R10190]
Reaction(KEGG)
Substrate
dTDP-6-deoxy-beta-L-talose [CPD:C03187];
NAD+ [CPD:C00003]
Product
dTDP-4-dehydro-beta-L-rhamnose [CPD:C00688];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.
History
EC 1.1.1.339 created 2012
Pathway
Polyketide sugar unit biosynthesis
Biosynthesis of antibiotics
Orthology
K19180  
dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
Genes
AAT: 
PPW: 
PFE: 
PMAN: 
PCG: 
PBC: 
PSV: 
PCH: 
PCZ: 
PCP: 
PSES: 
PSEM: 
PSOS: 
PKR: 
MEJ: 
ALV: 
MPUR: 
PNR: 
RDP: 
PKT: 
DSU: 
PCA: 
PPD: 
DAS: 
DEJ: 
DOL: 
MAMO: 
AVI: 
RHL: 
NGL: 
NGG: 
NHA: 
PHP: 
PAEN: 
SIK: 
SIQ: 
SIO: 
SIZ: 
SLU: 
LRM: 
LLF: 
BFI: 
DHD: 
ELM: 
MCHI: 
MTS: 
NML: 
ACQ: 
AOS: 
BLB: 
BAD: 
BBP: 
BBRJ: 
BPSP: 
BPSC: 
BSCA: 
GVG: 
GVH: 
CYI: 
ARP: 
OAC: 
MBF: 
SBU: 
EPO: 
NIA: 
FAE: 
FIB: 
CNI: 
MLA: 
 » show all
Taxonomy
Reference
1  [PMID:10702238]
  Authors
Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T
  Title
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans.
  Journal
J. Biol. Chem. 275 (2000) 6806-12.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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