KEGG   ENZYME: 1.1.1.340Help
Entry
EC 1.1.1.340                Enzyme                                 

Name
1-deoxy-11beta-hydroxypentalenate dehydrogenase;
1-deoxy-11beta-hydroxypentalenic acid dehydrogenase;
ptlF (gene name);
penF (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
1-deoxy-11beta-hydroxypentalenate:NAD+ oxidoreductase
Reaction(IUBMB)
1-deoxy-11beta-hydroxypentalenate + NAD+ = 1-deoxy-11-oxopentalenate + NADH + H+ [RN:R10156]
Reaction(KEGG)
Substrate
1-deoxy-11beta-hydroxypentalenate [CPD:C20403];
NAD+ [CPD:C00003]
Product
1-deoxy-11-oxopentalenate [CPD:C20400];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Isolated from the bacterium Streptomyces avermitilis and present in many other Streptomyces species. Part of the pathway for pentalenolactone biosynthesis.
History
EC 1.1.1.340 created 2012
Pathway
Biosynthesis of antibiotics
Orthology
K17747  
1-deoxy-11beta-hydroxypentalenate dehydrogenase
Genes
SMA: 
SBH: 
SCI: 
SCW: 
Taxonomy
Reference
1  [PMID:17178094]
  Authors
You Z, Omura S, Ikeda H, Cane DE
  Title
Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and  identification of a new biosynthetic intermediate.
  Journal
Arch. Biochem. Biophys. 459 (2007) 233-40.
  Sequence
[sma:SAV_2993]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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