KEGG   ENZYME: 1.1.1.342Help
Entry
EC 1.1.1.342                Enzyme                                 

Name
CDP-paratose synthase;
rfbS (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
CDP-alpha-D-paratose:NADP+ 4-oxidoreductase
Reaction(IUBMB)
CDP-alpha-D-paratose + NADP+ = CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADPH + H+ [RN:R04265]
Reaction(KEGG)
Substrate
CDP-alpha-D-paratose [CPD:C03598];
NADP+ [CPD:C00006]
Product
CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose [CPD:C04297];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in synthesis of paratose and tyvelose, unusual 3,6-dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria. Isolated from Salmonella enterica subsp. enterica serovar Typhi (Salmonella typhi).
History
EC 1.1.1.342 created 2012
Pathway
Amino sugar and nucleotide sugar metabolism
Orthology
K12453  
CDP-paratose synthetase
Genes
STY: 
STY2299(rfbS)
STT: 
t0783(rfbS)
SEX: 
SENT: 
SPT: 
SPA0777(rfbS)
SEK: 
SED: 
SEG: 
SEL: 
SPUL_0808(rfbS)
SEGA: 
SET: 
SEN2085D(rfbS)
SENA: 
SENO: 
SENV: 
SENQ: 
SENL: 
SENJ: 
SEEP: 
YPE: 
YPO3112(prt)
YPK: 
YPA: 
YPN: 
YPM: 
YP_0818(prt)
YPP: 
YPG: 
YPZ: 
YPT: 
YPD: 
YPX: 
YPH: 
YPW: 
YPJ: 
YPV: 
YPL: 
YPS: 
YPO: 
YPI: 
YPY: 
YPB: 
YPU: 
YPC: 
YPF: 
PIN: 
BMX: 
ASH: 
 » show all
Taxonomy
Reference
1  [PMID:2793833]
  Authors
Verma N, Reeves P
  Title
Identification and sequence of rfbS and rfbE, which determine antigenic specificity of group A and group D salmonellae.
  Journal
J. Bacteriol. 171 (1989) 5694-701.
  Sequence
[sty:STY2299]
Reference
2  [PMID:9538012]
  Authors
Hallis TM, Lei Y, Que NL, Liu H
  Title
Mechanistic studies of the biosynthesis of paratose: purification and characterization of CDP-paratose synthase.
  Journal
Biochemistry. 37 (1998) 4935-45.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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