KEGG   ENZYME: 1.1.1.349Help
Entry
EC 1.1.1.349                Enzyme                                 

Name
norsolorinic acid ketoreductase;
aflD (gene name);
nor-1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(1'S)-averantin:NADP+ oxidoreductase
Reaction(IUBMB)
(1'S)-averantin + NADP+ = norsolorinic acid + NADPH + H+ [RN:R10309]
Reaction(KEGG)
Substrate
(1'S)-averantin [CPD:C20499];
NADP+ [CPD:C00006]
Product
norsolorinic acid [CPD:C20452];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
History
EC 1.1.1.349 created 2013
Pathway
Aflatoxin biosynthesis
Orthology
K17644  
norsolorinic acid ketoreductase
Genes
SMP: 
PAN: 
TTT: 
MGR: 
NHE: 
VAL: 
BFU: 
ANI: 
AFM: 
AOR: 
AOR_1_24014(AO090026000011) AOR_1_98074(AO090038000063)
ANG: 
ANI_1_1984104(An12g06400)
AFV: 
ACT: 
NFI: 
PCS: 
URE: 
PNO: 
PTE: 
 » show all
Taxonomy
Reference
1  [PMID:8368836]
  Authors
Yabe K, Matsuyama Y, Ando Y, Nakajima H, Hamasaki T
  Title
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
  Journal
Appl. Environ. Microbiol. 59 (1993) 2486-92.
Reference
2  [PMID:10584035]
  Authors
Zhou R, Linz JE
  Title
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus  parasiticus.
  Journal
Appl. Environ. Microbiol. 65 (1999) 5639-41.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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