KEGG   ENZYME: 1.1.1.351Help
Entry
EC 1.1.1.351                Enzyme                                 

Name
phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase (decarboxylating)
Reaction(IUBMB)
6-phospho-D-gluconate + NAD(P)+ = D-ribulose 5-phosphate + CO2 + NAD(P)H + H+ [RN:R01528 R10221]
Reaction(KEGG)
Substrate
6-phospho-D-gluconate [CPD:C00345];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
D-ribulose 5-phosphate [CPD:C00199];
CO2 [CPD:C00011];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce reducing power and pentose for biosynthetic reactions. Unlike EC 1.1.1.44, phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), it is not specific for NADP+ and can accept both cofactors with similar efficiency. cf. EC 1.1.1.343, phosphogluconate dehydrogenase [NAD+-dependent, decarboxylating].
History
EC 1.1.1.351 created 2013
Reference
1  [PMID:7350909]
  Authors
Ben-Bassat A, Goldberg I
  Title
Purification and properties of glucose-6-phosphate dehydrogenase (NADP+/NAD+) and 6-phosphogluconate dehydrogenase (NADP+/NAD+) from methanol-grown Pseudomonas C.
  Journal
Biochim. Biophys. Acta. 611 (1980) 1-10.
Reference
2  [PMID:6402366]
  Authors
Stournaras C, Maurer P, Kurz G
  Title
6-phospho-D-gluconate dehydrogenase from Pseudomonas fluorescens. Properties and  subunit structure.
  Journal
Eur. J. Biochem. 130 (1983) 391-6.
Reference
3  [PMID:8579362]
  Authors
Levy HR, Vought VE, Yin X, Adams MJ
  Title
Identification of an arginine residue in the dual coenzyme-specific glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides that plays a key role in binding NADP+ but not NAD+.
  Journal
Arch. Biochem. Biophys. 326 (1996) 145-51.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9073-95-4

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