KEGG   ENZYME: 1.1.1.353Help
Entry
EC 1.1.1.353                Enzyme                                 

Name
versiconal hemiacetal acetate reductase;
VHA reductase;
VHA reductase I;
VHA reductase II;
vrdA (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
versiconol-acetate:NADP+ oxidoreductase
Reaction(IUBMB)
(1) versicolorone + NADP+ = 1'-hydroxyversicolorone + NADPH + H+ [RN:R09756];
(2) versiconol acetate + NADP+ = versiconal hemiacetal acetate + NADPH + H+ [RN:R10399];
(3) versiconol + NADP+ = versiconal + NADPH + H+ [RN:R10400]
Reaction(KEGG)
Substrate
versicolorone [CPD:C20504];
NADP+ [CPD:C00006];
versiconol acetate [CPD:C20506];
versiconol [CPD:C20508]
Product
1'-hydroxyversicolorone [CPD:C20503];
NADPH [CPD:C00005];
H+ [CPD:C00080];
versiconal hemiacetal acetate [CPD:C20505];
versiconal [CPD:C20507]
Comment
Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.
History
EC 1.1.1.353 created 2013
Pathway
Aflatoxin biosynthesis
Orthology
K17647  
versiconal hemiacetal acetate reductase
Genes
AOR: 
AOR_1_2094(AO090120000002)
AFV: 
Taxonomy
Reference
1  [PMID:16349333]
  Authors
Matsushima K, Ando Y, Hamasaki T, Yabe K
  Title
Purification and characterization of two versiconal hemiacetal acetate reductases involved in aflatoxin biosynthesis.
  Journal
Appl. Environ. Microbiol. 60 (1994) 2561-7.
  Sequence
Reference
2  [PMID:19211038]
  Authors
Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K
  Title
Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster.
  Journal
Fungal. Genet. Biol. 46 (2009) 221-31.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system