KEGG   ENZYME: 1.1.1.354Help
Entry
EC 1.1.1.354                Enzyme                                 

Name
farnesol dehydrogenase (NAD+);
NAD+-farnesol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2E,6E)-farnesol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+ [RN:R10412]
Reaction(KEGG)
Substrate
(2E,6E)-farnesol [CPD:C01126];
NAD+ [CPD:C00003]
Product
(2E,6E)-farnesal [CPD:C03461];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.
History
EC 1.1.1.354 created 2013
Pathway
Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
Orthology
K15891  
NAD+-dependent farnesol dehydrogenase
Genes
ATH: 
AT4G33360(FLDH)
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj1g3v1649010.1(Lj1g3v1649010.1) Lj1g3v1649010.2(Lj1g3v1649010.2) Lj1g3v2584610.1(Lj1g3v2584610.1) Lj1g3v2584640.1(Lj1g3v2584640.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0002s12890g(POPTRDRAFT_644137) POPTR_0002s12900g(POPTRDRAFT_798897)
VVI: 
SLY: 
SPEN: 
SOT: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os03t0184550-01(Os03g0184550)
OBR: 
BDI: 
ATS: 
SBI: 
SORBI_01g044880(SORBIDRAFT_01g044880) SORBI_01g044900(SORBIDRAFT_01g044900)
ZMA: 
100272889(GRMZM2G109589)
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
 » show all
Taxonomy
Reference
1  [PMID:18422649]
  Authors
Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y
  Title
Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae).
  Journal
FEBS. J. 275 (2008) 2807-17.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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