KEGG   ENZYME: 1.1.1.354Help
Entry
EC 1.1.1.354                Enzyme                                 

Name
farnesol dehydrogenase (NAD+);
NAD+-farnesol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2E,6E)-farnesol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
(2E,6E)-farnesol + NAD+ = (2E,6E)-farnesal + NADH + H+ [RN:R10412]
Reaction(KEGG)
Substrate
(2E,6E)-farnesol [CPD:C01126];
NAD+ [CPD:C00003]
Product
(2E,6E)-farnesal [CPD:C03461];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the prune mite Carpoglyphus lactis also acts on geraniol with greater activity [cf. EC 1.1.1.347, geraniol dehydrogenase (NAD+)]. Unlike EC 1.1.1.216, farnesol dehydrogenase (NADP+), this enzyme cannot use NADP+ as cofactor.
History
EC 1.1.1.354 created 2013
Reference
1  [PMID:18422649]
  Authors
Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y
  Title
Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae).
  Journal
FEBS. J. 275 (2008) 2807-17.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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