KEGG   ENZYME: 1.1.1.357Help
Entry
EC 1.1.1.357                Enzyme                                 

Name
3alpha-hydroxysteroid 3-dehydrogenase;
3alpha-hydroxysteroid dehydrogenase;
AKR1C4 (gene name);
AKR1C2 (gene name);
hsdA (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase
Reaction(IUBMB)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R10422 R10423]
Reaction(KEGG)
Substrate
3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. This entry stands for enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known. [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) and EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)].
History
EC 1.1.1.357 created 2013
Orthology
K00037  
3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
K00089  
3alpha-hydroxysteroid 3-dehydrogenase
K00212  
20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase
K04119  
aldo-keto reductase family 1 member C3
K19811  
3alpha-hydroxysteroid 3-dehydrogenase
Genes
HSA: 
1109(AKR1C4) 1645(AKR1C1) 1646(AKR1C2) 8644(AKR1C3)
PTR: 
100607996(AKR1C1) 100612718(AKR1C3) 450274(AKR1C4)
PPS: 
GGO: 
PON: 
100171658(AKR1C1) 100174617(AKR1C3)
NLE: 
100604844(AKR1C3) 100605385(AKR1C4) 100605934(AKR1C1)
MCC: 
711198(AKR1C1) 711440(AKR1C3)
MCF: 
101865536(AKR1C1) 102116465(AKR1C2) 102117205(AKR1C4) 102142023(HSD17B5)
CSAB: 
RRO: 
CJC: 
SBQ: 
NGI: 
HGL: 
OCU: 
100352458(PGER4)
TUP: 
CFA: 
497070(AKR1C3)
FCA: 
100510801(AKR1C3)
PTG: 
BTA: 
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
LAV: 
OAA: 
PSS: 
CMY: 
GJA: 
XTR: 
779627(akr1c3)
CTT: 
CTES: 
 » show all
Taxonomy
Reference
1  [PMID:8172617]
  Authors
Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A
  Title
Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.
  Journal
Biochem. J. 299 ( Pt 2) (1994) 545-52.
  Sequence
[hsa:1645 1109]
Reference
2  [PMID:7650035]
  Authors
Khanna M, Qin KN, Wang RW, Cheng KC
  Title
Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.
  Journal
J. Biol. Chem. 270 (1995) 20162-8.
  Sequence
[hsa:8644]
Reference
3  [PMID:8944761]
  Authors
Oppermann UC, Maser E
  Title
Characterization of a 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from the gram-negative bacterium Comamonas testosteroni.
  Journal
Eur. J. Biochem. 241 (1996) 744-9.
  Sequence
Reference
4  [PMID:9812981]
  Authors
Mobus E, Maser E
  Title
Molecular cloning, overexpression, and characterization of steroid-inducible 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni. A novel member of the short-chain dehydrogenase/reductase superfamily.
  Journal
J. Biol. Chem. 273 (1998) 30888-96.
  Sequence
Reference
5  [PMID:11514561]
  Authors
Nahoum V, Gangloff A, Legrand P, Zhu DW, Cantin L, Zhorov BS, Luu-The V, Labrie F, Breton R, Lin SX
  Title
Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.
  Journal
J. Biol. Chem. 276 (2001) 42091-8.
  Sequence
[hsa:1646]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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