Entry |
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Name |
aldose 1-dehydrogenase [NAD(P)+]
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
an aldopyranose:NAD(P)+ 1-oxidoreductase
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Reaction(IUBMB) |
an aldopyranose + NAD(P)+ = an aldono-1,5-lactone + NAD(P)H + H+ [RN: R10428 R10429]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity towards aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD+ and NADP+ with similar catalytic efficiency. It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.
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History |
EC 1.1.1.359 created 2013
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Pathway |
| Pentose phosphate pathway | | Galactose metabolism | | Metabolic pathways | | Biosynthesis of secondary metabolites | | Biosynthesis of antibiotics |
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Orthology |
| aldose 1-dehydrogenase [NAD(P)+] |
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Genes |
PTO: | | FAC: | | FAI: | | CDIV: | | SSO: | | SOL: | | SSOA: | | SSOL: | | SSOF: | | STO: | | SAI: | | SACN: | | SACR: | | SACS: | | SIS: | | SIA: | | SIM: | | SID: | | SIY: | | SIN: | | SII: | | SIH: | | SIR: | | SIC: | | SULA: | | MSE: | | MCN: | | AHO: | | AMAN: | | CMA: | | » show all
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Reference |
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Authors |
Giardina P, de Biasi MG, de Rosa M, Gambacorta A, Buonocore V |
Title |
Glucose dehydrogenase from the thermoacidophilic archaebacterium Sulfolobus solfataricus. |
Journal |
Biochem. J. 239 (1986) 517-22. |
Reference |
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Authors |
Smith LD, Budgen N, Bungard SJ, Danson MJ, Hough DW |
Title |
Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum. |
Journal |
Biochem. J. 261 (1989) 973-7. |
Reference |
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Authors |
Lamble HJ, Heyer NI, Bull SD, Hough DW, Danson MJ |
Title |
Metabolic pathway promiscuity in the archaeon Sulfolobus solfataricus revealed by studies on glucose dehydrogenase and 2-keto-3-deoxygluconate aldolase. |
Journal |
J. Biol. Chem. 278 (2003) 34066-72. |
Sequence |
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Reference |
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Authors |
Theodossis A, Milburn CC, Heyer NI, Lamble HJ, Hough DW, Danson MJ, Taylor GL |
Title |
Preliminary crystallographic studies of glucose dehydrogenase from the promiscuous Entner-Doudoroff pathway in the hyperthermophilic archaeon Sulfolobus solfataricus. |
Journal |
Acta. Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 61 (2005) 112-5. |
Reference |
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Authors |
Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL |
Title |
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. |
Journal |
J. Biol. Chem. 281 (2006) 14796-804. |
Sequence |
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Reference |
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Authors |
Haferkamp P, Kutschki S, Treichel J, Hemeda H, Sewczyk K, Hoffmann D, Zaparty M, Siebers B |
Title |
An additional glucose dehydrogenase from Sulfolobus solfataricus: fine-tuning of sugar degradation? |
Journal |
Biochem. Soc. Trans. 39 (2011) 77-81. |
Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |