KEGG   ENZYME: 1.1.1.362Help
Entry
EC 1.1.1.362                Enzyme                                 

Name
aklaviketone reductase;
dauE (gene name);
aknU (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
aklavinone:NADP+ oxidoreductase
Reaction(IUBMB)
aklavinone + NADP+ = aklaviketone + NADPH + H+ [RN:R06682]
Reaction(KEGG)
R06682;
(other) R06677
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Substrate
aklavinone [CPD:C12424];
NADP+ [CPD:C00006]
Product
aklaviketone [CPD:C12423];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin.
History
EC 1.1.1.362 created 2013
Pathway
Biosynthesis of type II polyketide products
Biosynthesis of antibiotics
Orthology
K15944  
nogalaviketone/aklaviketone reductase
Genes
MAU: 
MIL: 
Taxonomy
Reference
1  [PMID:8655529]
  Authors
Dickens ML, Ye J, Strohl WR.
  Title
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.
  Journal
J. Bacteriol. 178 (1996) 3384-8.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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