KEGG   ENZYME: 1.1.1.364Help
Entry
EC 1.1.1.364                Enzyme                                 

Name
dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase;
dTDP-4-dehydro-6-deoxygulose reductase;
tylD (gene name);
gerKI (gene name);
chmD (gene name);
mydI (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
dTDP-6-deoxy-alpha-D-allose:NAD(P)+ oxidoreductase
Reaction(IUBMB)
dTDP-6-deoxy-alpha-D-allose + NAD(P)+ = dTDP-4-dehydro-6-deoxy-alpha-D-gulose + NAD(P)H + H+ [RN:R06438 R10573]
Reaction(KEGG)
Substrate
dTDP-6-deoxy-alpha-D-allose [CPD:C11912];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
dTDP-4-dehydro-6-deoxy-alpha-D-gulose [CPD:C11926];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme forms an activated deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.
History
EC 1.1.1.364 created 2013
Pathway
Polyketide sugar unit biosynthesis
Biosynthesis of antibiotics
Orthology
K13313  
dTDP-4-dehydro-6-deoxy-alpha-D-gulose 4-ketoreductase
Genes
STRM: 
AMI: 
Taxonomy
Reference
1  [PMID:10510490]
  Authors
Bate N, Cundliffe E
  Title
The mycinose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
J. Ind. Microbiol. Biotechnol. 23 (1999) 118-122.
  Sequence
Reference
2  [PMID:12583909]
  Authors
Anzai Y, Saito N, Tanaka M, Kinoshita K, Koyama Y, Kato F.
  Title
Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in Micromonospora griseorubida.
  Journal
FEMS. Microbiol. Lett. 218 (2003) 135-41.
  Sequence
Reference
3  [PMID:17053005]
  Authors
Thuy TT, Liou K, Oh TJ, Kim DH, Nam DH, Yoo JC, Sohng JK
  Title
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.
  Journal
Glycobiology. 17 (2007) 119-26.
  Sequence
Reference
4  [PMID:23116432]
  Authors
Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM
  Title
Structural and functional studies on a 3'-epimerase involved in the biosynthesis  of dTDP-6-deoxy-D-allose.
  Journal
Biochemistry. 51 (2012) 9375-83.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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