KEGG   ENZYME: 1.1.1.369Help
Entry
EC 1.1.1.369                Enzyme                                 

Name
D-chiro-inositol 1-dehydrogenase;
DCI 1-dehydrogenase;
IolG
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
1D-chiro-inositol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
1D-chiro-inositol + NAD+ = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+ [RN:R09951]
Reaction(KEGG)
Substrate
1D-chiro-inositol [CPD:C19891];
NAD+ [CPD:C00003]
Product
2D-2,3,5/4,6-pentahydroxycyclohexanone [CPD:C20251];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, found in the bacterium Bacillus subtilis, also catalyses the reaction of EC 1.1.1.18, inositol 2-dehydrogenase, and can also use D-glucose and D-xylose. It shows trace activity with D-ribose and D-fructose [1]. It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.
History
EC 1.1.1.369 created 2014
Pathway
ec00562  Inositol phosphate metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K00010  myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase
Genes
ACYG: 106047244
PHI: 106628441
CCW: 104693287
FPG: 106112543
FCH: 106631068
CLV: 102084251
BFO: BRAFLDRAFT_69830
CIN: 100181790
SPU: 100893698
APLC: 110978999 110979000
AME: 552024(GB19935)
BIM: 100746370
BTER: 100644470
SOC: 105192997
PBAR: 105424859
HST: 105191414
CFO: 105258709
LHU: 105679763
PGC: 109861873
NVI: 100120331
TCA: 658577
PMAC: 106708726
PRAP: 110992880
PXY: 105397960
FCD: 110843109
ADF: 107347122
HMG: 100202546
MAW: MAC_01567
MAJ: MAA_02404
CMT: CCM_03114
ANG: ANI_1_676144(An16g04750)
PTE: PTT_19222
SMIN: v1.2.008936.t1(symbB.v1.2.008936.t1) v1.2.008937.t1(symbB.v1.2.008937.t1)
FCY: FRACYDRAFT_181045(InDH1)
SPAR: SPRG_02029
SEY: SL1344_4357(iolG1) SL1344_4363(iolG2)
ENC: ECL_03807(iolG)
EEC: EcWSU1_03315(idhA)
CSK: ES15_3056(iolG)
CTU: CTU_08980(iolG)
KPE: KPK_4081(idhA) KPK_4990(idh)
KPR: KPR_0652(iolG) KPR_4054
KPX: PMK1_02143(iolG) PMK1_02833(idhA)
KPNK: BN49_1549 BN49_4762(iolG)
EAE: EAE_09820
EAR: CCG32072
CKO: CKO_03991
CWE: CO701_04345(iolG)
LNI: CWR52_18630(iolG)
YPS: YPTB1073
YPO: BZ17_1470(iolG)
YPY: YPK_3046
YPB: YPTS_1129
YPQ: DJ40_1200
YPU: BZ21_323(iolG)
YPR: BZ20_953(iolG)
YPC: BZ23_601(iolG)
YPF: BZ19_431(iolG)
YEN: YE4026(idh)
YEY: Y11_31711
YEW: CH47_3706
YET: CH48_1477
YAL: AT01_2642
YFR: AW19_3425
YIN: CH53_1593
YKR: CH54_2365
YRO: CH64_2439
SRL: SOD_c22250(yisS) SOD_c29110(yrbE) SOD_c44560(iolG)
SPLY: Q5A_012440(iolX_1) Q5A_016175(idhA) Q5A_024260(iolG)
SMAF: D781_4370
SMAR: SM39_4126(iolG)
SMAC: SMDB11_3902(iolG)
SERF: L085_03310
SERA: Ser39006_021295(iolG)
ECA: ECA1458(idhA)
PATR: EV46_07385
PATO: GZ59_14970(idhA)
PCT: PC1_1336
DDD: Dda3937_01203(idhA)
DDQ: DDI_0578
DFN: CVE23_04270(iolG)
ETA: ETA_32880(iolG)
EPY: EpC_34990(iolG)
EPR: EPYR_03758(iolG)
EAM: EAMY_3507(iolG)
EAY: EAM_3304(idh)
ERJ: EJP617_09790(iolG)
PAM: PANA_3736(idh)
PLF: PANA5342_0306(idh)
PAJ: PAJ_2960(idh)
PSTW: DSJ_01300
PLU: plu1804
PAY: PAU_02711(idhA)
XBV: XBW1_1516(idhA)
XNE: XNC1_2983
XNM: XNC2_2863
XDO: XDD1_1039(idhA)
XPO: XPG1_3268(idhA)
PSI: S70_04170
PSX: DR96_12
PRG: RB151_031070(idhA)
ETE: ETEE_3694(iolG)
PSHI: SAMEA2665130_0885(idhA)
HAP: HAPS_1534(iolG)
HPAZ: K756_10580
HPAS: JL26_09115
HPAK: JT17_07240
HSO: HS_1576(iolG)
HSM: HSM_0435
MHT: D648_2440(iolG)
MHQ: D650_25700(iolG)
MHAT: B824_24180(iolG)
MHAE: F382_06900
MHAM: J450_08140
MHAO: J451_09325
MHAL: N220_01185
MHAQ: WC39_12880
MHAY: VK67_12885
MVI: X808_1640
MVG: X874_1720
AAT: D11S_1813
AAN: D7S_00598
AACN: AANUM_1310
BTO: WQG_22450
BTRE: F542_160
BTRH: F543_170
BTRA: F544_22970
VHR: AL538_18380(iolG)
VNI: VIBNI_A2174(idhA)
VAN: VAA_01471
PPR: PBPRB0470(AGR_L_16)
GHO: AL542_13960(iolG)
PPUN: PP4_21500(idhA)
PSB: Psyr_3268
PSYR: N018_16400
PFL: PFL_2591(iolG)
PPRC: PFLCHA0_c26560(iolG)
PPRO: PPC_2638(iolG)
PMAN: OU5_0762
PSES: PSCI_0432(iolG) PSCI_5140
PSEM: TO66_12615
PSOS: POS17_2596(iolG)
PANR: A7J50_2471
PTN: PTRA_b0320(iolG)
LPN: lpg1652
LPH: LPV_1908(iolG)
LPO: LPO_1688(iolG)
LPM: LP6_1630
LPF: lpl1618(iolG)
LPP: lpp1623(iolG)
LPC: LPC_1082(iolG)
LPA: lpa_02388
LPE: lp12_1590
LLO: LLO_2235(iolG)
LFA: LFA_1673(yrbE)
LHA: LHA_0078(yrbE)
LSH: CAB17_16505(iolG)
GAI: IMCC3135_06330(idhA_1) IMCC3135_16520(idhA_2)
HCH: HCH_05773
HEL: HELO_4239(idhA)
HAM: HALO0568
HBE: BEI_3717(iolG)
RFO: REIFOR_03270(iolG1)
RSO: RSc1246(iolG)
RSM: CMR15_10832(idh) CMR15_20452(idh)
RSE: F504_1274
BMA: BMA0918
BMAF: DM51_673(iolG) DM51_674
BMAB: BM45_1895 BM45_1896(iolG)
BPK: BBK_34 BBK_35(idhA)
BPSA: BBU_694 BBU_695(idhA)
BUT: X994_1167 X994_1168(iolG)
BTQ: BTQ_1382(idhA) BTQ_1383
BTJ: BTJ_1069 BTJ_1070(idhA)
BTHM: BTRA_2590 BTRA_2591(idhA)
BTHL: BG87_2534 BG87_2535(iolG)
BOC: BG90_3648 BG90_3649(iolG)
BVE: AK36_2552
BCJ: BCAL0917 BCAL1435(idh)
BCEW: DM40_2053
BCEO: I35_1333(idh) I35_2751
BMJ: BMULJ_01354(iolG) BMULJ_02649(iolG)
BMUL: NP80_1509 NP80_2821(iolG)
BCT: GEM_2002
BDL: AK34_1744 AK34_402(iolG)
BUB: BW23_313 BW23_314(iolG)
BLAT: WK25_06965
BTEI: WS51_17370
BSEM: WJ12_07040
BPSL: WS57_25370
BSTG: WT74_07205
BGU: KS03_3032 KS03_3033(iolG)
BUK: MYA_1261
BUL: BW21_2351 BW21_2352(iolG)
BFN: OI25_2618(iolG) OI25_2619
DAC: Daci_2925
JAG: GJA_2990(idhA) GJA_2991
CFU: CFU_1934(idhA) CFU_1935
SME: SM_b20899(idhA)
SMX: SM11_pD0405(idhA)
SMI: BN406_05481(idhA) BN406_06727(idhA) BN406_06786(iolG1)
SMEL: SM2011_b20899(idhA)
SMER: DU99_27465
EAD: OV14_3940(idhA2)
ATU: Atu4012(idhA) Atu4554(iolG)
ARA: Arad_0103(idhA) Arad_0116 Arad_3362(idhA) Arad_8534(idhA)
ATF: Ach5_37920(idhA) Ach5_42500(iolG) Ach5_50230(iolG)
AVI: Avi_0074(idhA)
AGC: BSY240_3765(iolG)
REI: IE4771_CH03436(idhA-1) IE4771_PD00541(idhA-2) IE4771_PE00638(iolG)
REP: IE4803_CH03396(idhA-1) IE4803_PC00529(idhA-2)
RLE: RL3622(idhA)
RIR: BN877_II0197(iolG1) BN877_II1138(idhA) BN877_p0454(iolG2) BN877_p0464(iolG3)
RHL: LPU83_2622(iolG) LPU83_3066(idhA) LPU83_pLPU83c0016(idhA)
RGA: RGR602_CH02786(idhA-1) RGR602_PC00305(idhA-2) RGR602_PC00463(iolG) RGR602_PC00474(idhA-3)
RHN: AMJ98_CH03327(idhA) AMJ98_PB00240(iolG)
RPHA: AMC79_CH03335(idhA-1) AMC79_PA00280(iolG) AMC79_PD00692(idhA-2)
RHT: NT26_3241(idhA)
RHX: AMK02_CH03261(idhA) AMK02_PB00254(iolG)
BME: BMEII0574
BMEL: DK63_2673(idhA)
BMEE: DK62_2729(idhA)
BMF: BAB2_0528
BMB: BruAb2_0519(idhA)
BABO: DK55_2507(idhA)
BABR: DO74_2922(idhA)
BABT: DK49_2732(idhA)
BABB: DK48_2184(idhA)
BABU: DK53_2510(idhA)
BABS: DK51_3094(idhA)
BABC: DO78_2548(idhA)
BMS: BRA0711(idhA)
BSI: BS1330_II0704(idhA)
BSF: BSS2_II0676(idhA)
BSZ: DK67_2676(idhA)
BSV: BSVBI22_B0703(idhA)
BOV: BOV_A0667(idhA)
BCS: BCAN_B0716(mocA)
BOL: BCOUA_II0711(idhA)
BCAR: DK60_2411(idhA)
BCAS: DA85_13875
BMR: BMI_II705(idhA)
BPP: BPI_II765(idhA)
BPV: DK65_2926(idhA)
OAN: Oant_3835
OAH: DR92_2656(idhA)
BRA: BRADO2244(idhA)
BBT: BBta_0488(idhA)
BRAD: BF49_1336
BOS: BSY19_690(iolG)
MNO: Mnod_7807
BID: Bind_2828
PHL: KKY_277
DEI: C4375_19200(iolG)
MMED: Mame_02148(idhA)
HDI: HDIA_1422(idhA)
CCR: CC_1296
CCS: CCNA_01354(idhA)
JAN: Jann_1416
RDE: RD1_0217(idhA) RD1_3876
RLI: RLO149_c000100(idhA)
PDE: Pden_1678
PARU: CYR75_05195(iolG)
DSH: Dshi_1265(idhA)
PSF: PSE_1809
PGA: PGA1_c07210(idhA)
PGL: PGA2_c06710(idhA)
PGD: Gal_02771
PHP: PhaeoP97_02471(idhA)
PPIC: PhaeoP14_00641(idhA)
OTM: OSB_26480(idhA)
PTP: RCA23_c00380(idhA)
MALG: MALG_02251
LVS: LOKVESSMR4R_00620(idhA)
GEH: HYN69_14615(iolG)
SMAZ: LH19_12530
SPHO: C3E99_18745(iolG)
SPHI: TS85_08295
GOX: GOX1187
AMV: ACMV_25520(iolG) ACMV_25620(idhA) ACMV_P1_00990(idhA) ACMV_P1_01120(iolG) ACMV_P1_01370(iolG)
GDI: GDI0366(idhA)
GDJ: Gdia_2417
AZL: AZL_b00980(iolG)
TXI: TH3_14075
THAC: CSC3H3_21650(iolG)
NAO: Y958_30120(iolG)
BSU: BSU27770(yrbE) BSU39700(iolG)
BSH: BSU6051_27770(yrbE) BSU6051_39700(iolG)
BSUT: BSUB_02962(yrbE) BSUB_04212(iolG)
BSUL: BSUA_02962(yrbE) BSUA_04212(iolG)
BSS: BSUW23_02820(idh) BSUW23_13450(yrbE) BSUW23_19810(iolG)
BSO: BSNT_09178(yrbE) BSNT_10657(idh)
BSQ: B657_27770(yrbE) B657_39700(iolG)
BSX: C663_2618(yrbE) C663_3889(iolG)
BLI: BL00240(idh)
BLD: BLi04245(iolG)
BLH: BaLi_c42360(iolG)
BAY: RBAM_036720(iolG)
BAQ: BACAU_3686(iolG)
BYA: BANAU_3856(iolG)
BAMP: B938_18830
BAML: BAM5036_3592(iolG)
BAMA: RBAU_3799(iolG)
BAMN: BASU_3581(iolG)
BAMB: BAPNAU_3863(iolG)
BAMT: AJ82_20715
BAMY: V529_39390(iolG)
BMP: NG74_03846(iolG)
BAO: BAMF_3782(iolG)
BAZ: BAMTA208_20000(iolG)
BQL: LL3_04105(iolG)
BXH: BAXH7_04103(iolG)
BQY: MUS_4361(iolG)
BAMI: KSO_000730
BAMC: U471_38310
BAMF: U722_19560
BATR: TD68_16750
BHA: BH2220 BH2221 BH2316(iolG)
BAN: BA_2511
BAR: GBAA_2511
BAT: BAS2332
BAI: BAA_2567
BANT: A16_25390
BANR: A16R_25700
BANS: BAPAT_2401
BANV: DJ46_1291
BCX: BCA_2596
BCF: bcf_12575
BCER: BCK_22300
BTL: BALH_2257
BTM: MC28_G008
BTW: BF38_3697
BWW: bwei_1728(iolG)
BCL: ABC0427(iolG)
BMQ: BMQ_0488(iolG) BMQ_3466(iolG) BMQ_pBM70037
BMD: BMD_0491(iolG) BMD_3461(iolG)
BMH: BMWSH_4752(iolG)
BMEG: BG04_2782(iolG)
BACP: SB24_10400
BACB: OY17_02035
BACL: BS34A_30310(yrbE) BS34A_42960(iolG)
BGY: BGLY_4630(iolG)
ANM: GFC28_268(iolG) GFC28_273(iolG)
ANL: GFC29_1351(iolG) GFC29_1356(iolG)
VPN: A21D_00412(idhA_1) A21D_00414(idhA_2)
SXO: SXYL_00038(iolG)
PMW: B2K_29175
PSWU: SY83_05985
PDH: B9T62_31155(iolG)
LCB: LCABL_02210(iolG1) LCABL_02220(iolG2)
LCW: BN194_02270(iolG) BN194_02280(yrbE)
LRH: LGG_00266(iolG1) LGG_00267(iolG2)
LRL: LC705_00257(iolG1) LC705_00258(iolG2)
LRA: LRHK_268(iolG) LRHK_269(iolG1)
EFI: OG1RF_11783(iolG) OG1RF_11784(iolG2)
EFN: DENG_02296(iolG) DENG_02297(iolG)
THL: TEH_11620(idh)
CBK: CLL_A1305
CBT: CLH_1256
CBE: Cbei_4547
CBZ: Cbs_4547
CBEI: LF65_05075
CPAT: CLPA_c10950(iolG)
CPAE: CPAST_c10950(iolG)
CSB: CLSA_c12150(yrbE1)
CTAE: BGI42_06005(iolG)
CSD: Clst_0989
CTHD: CDO33_05895(iolG)
BHU: bhn_I0097
TAE: TepiRe1_0711(yrbE)
CSC: Csac_2738
MHG: MHY_06490
LPIL: LIP_2020
CGL: NCgl0161(Cgl0164) NCgl2029(Cgl2110) NCgl2957(Cgl3062) NCgl2958(Cgl3063)
CGB: cg0204(iolG) cg2313(idhA3) cg3391(idhA1) cg3392(idhA2)
CGU: WA5_0161(IolG) WA5_2029(IdhA3) WA5_2957(IdhA1) WA5_2958(IdhA2)
CGM: cgp_0204(iolG) cgp_2313(idhA3) cgp_3391(idhA1) cgp_3392(idhA2)
CAMG: CAMM_03525
ROP: ROP_05130(idh) ROP_05170(idh) ROP_10710(idh) ROP_37550(idh) ROP_53120
RHU: A3Q40_02115(iolG_1) A3Q40_02120(iolX) A3Q40_02133(iolG_2)
GPO: GPOL_c34660(iolG1) GPOL_c34760(iolG2)
TPR: Tpau_1361
SCO: SCO6255(SCAH10.20c) SCO6984(SC8F11.10c) SCO7254(SC5H1.38)
SMA: SAVERM_1234(iolG1) SAVERM_1985 SAVERM_7188(iolG2)
SGR: SGR_1277 SGR_5937(strI)
SGB: WQO_28860
SCT: SCAT_4794 SCAT_4795(iolG)
SFA: Sfla_1017
SVE: SVEN_6120
SALB: XNR_0558
SALS: SLNWT_0563
STRP: F750_5829
SFI: SFUL_6205
SPRI: SPRI_1419
SRW: TUE45_00977(iolG_1) TUE45_06876(idhA_1) TUE45_07381(idhA_2)
SLE: sle_01710(sle_01710) sle_14250(sle_14250) sle_64630(sle_64630)
SRN: A4G23_04847(idhA)
SLAU: SLA_6197
SALF: SMD44_00636(iolG) SMD44_06889(iolG)
SALJ: SMD11_4428(iolG) SMD11_4429(iolG)
SLX: SLAV_08635(idhA) SLAV_24075(iolG)
LXX: Lxx24320
CMI: CMM_0793
CMC: CMN_00749
ARX: ARZXY2_2023(iolG) ARZXY2_2949(iolG) ARZXY2_2956(iolG) ARZXY2_3548(iolG) ARZXY2_3550(iolG)
LMOI: VV02_10200
PAC: PPA0469
PAK: HMPREF0675_3511(idhA)
PAW: PAZ_c04890(iolG4)
PACC: PAC1_02410
PACH: PAGK_0486
CACN: RN83_02845
PFR: PFREUD_19030(iolG1)
MPH: MLP_04380(idh) MLP_23630(idh) MLP_27190(idh) MLP_28260(idh)
SEN: SACE_2980(iolG) SACE_3276(idhA2) SACE_4537(iolG) SACE_4657(iolG) SACE_5193(iolG)
AMD: AMED_1890(iolG)
AMN: RAM_09590
AMM: AMES_1876(iolG)
AMZ: B737_1877(iolG)
AOI: AORI_5988(iolG)
AMQ: AMETH_3781(iolG)
PSEA: WY02_00740
AMI: Amir_6853
KAL: KALB_8538
SAQ: Sare_2488
AMS: AMIS_48550(iolG)
ASE: ACPL_2914(iolG)
ACTN: L083_4757(iolG)
ACTS: ACWT_2632
CAI: Caci_4486
SNA: Snas_0653
AHE: Arch_0042
BBI: BBIF_1355(iolG)
BBP: BBPR_1400
BBF: BBB_1382(iolG)
TBI: Tbis_3080
AVA: Ava_0798
ABAT: CFX1CAM_0766(yrbE)
CAP: CLDAP_26020(iolG) CLDAP_26130(iolG) CLDAP_26150(iolG)
SACI: Sinac_1047
ABAC: LuPra_05227(idhA_2)
GBA: J421_0862
ASH: AL1_00830
DFE: Dfer_5698
LBY: Lbys_0019
TMA: TM0414
TMW: THMA_0420
TMQ: THMB_0420
TMX: THMC_0420
TPT: Tpet_0506
TNA: CTN_0255
TNP: Tnap_0206
KOL: Kole_0987
CMA: Cmaq_0681
TPE: Tpen_1013
LOKI: Lokiarch_13940(idhA)
 » show all
Taxonomy
Reference
1  [PMID:112095]
  Authors
Ramaley R, Fujita Y, Freese E
  Title
Purification and properties of Bacillus subtilis inositol dehydrogenase.
  Journal
J. Biol. Chem. 254 (1979) 7684-90.
Reference
2  [PMID:16461681]
  Authors
Yoshida K, Yamaguchi M, Morinaga T, Ikeuchi M, Kinehara M, Ashida H
  Title
Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an  investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome.
  Journal
Appl. Environ. Microbiol. 72 (2006) 1310-5.
  Sequence
[bsu:BSU39700]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.369
IUBMB Enzyme Nomenclature: 1.1.1.369
ExPASy - ENZYME nomenclature database: 1.1.1.369
BRENDA, the Enzyme Database: 1.1.1.369

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