KEGG   ENZYME: 1.1.1.370Help
Entry
EC 1.1.1.370                Enzyme                                 

Name
scyllo-inositol 2-dehydrogenase (NAD+);
iolX (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
scyllo-inositol:NAD+ 2-oxidoreductase
Reaction(IUBMB)
scyllo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+ [RN:R09953]
Reaction(KEGG)
Substrate
scyllo-inositol [CPD:C06153];
NAD+ [CPD:C00003]
Product
2,4,6/3,5-pentahydroxycyclohexanone [CPD:C00691];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, found in the bacterium Bacillus subtilis, has no activity with NADP+ [cf. EC 1.1.1.371, scyllo-inositol 2-dehydrogenase (NADP+)]. It is part of a scyllo-inositol degradation pathway leading to acetyl-CoA.
History
EC 1.1.1.370 created 2014
Pathway
Inositol phosphate metabolism
Microbial metabolism in diverse environments
Orthology
K16043  
scyllo-inositol 2-dehydrogenase (NAD+)
Genes
BSU: 
BSU10850(yisS)
BSR: 
BSL: 
BSH: 
BSY: 
BSUT: 
BSUL: 
BSUS: 
BSS: 
BST: 
BSO: 
BSN: 
BSQ: 
BSX: 
C663_1108(yisS)
BSP: 
BLI: 
BL01338(yisS)
BLD: 
BLi01181(yisS)
BLH: 
BAQ: 
BYA: 
BAMB: 
BMP: 
BAO: 
BAMF_1169(yisS)
BAZ: 
BQL: 
LL3_01173(yisS)
BXH: 
BQY: 
MUS_1133(yisS)
BAMI: 
BAMF: 
BAE: 
BATR: 
BCL: 
BJS: 
BLE: 
GST: 
BACB: 
BACY: 
BACL: 
BALM: 
GKA: 
GMC: 
GSE: 
GSR: 
DKU: 
CAP: 
MRE: 
SSM: 
SCC: 
 » show all
Taxonomy
Reference
1  [PMID:20133360]
  Authors
Morinaga T, Ashida H, Yoshida K.
  Title
Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis.
  Journal
Microbiology. 156 (2010) 1538-46.
  Sequence
[bsu:BSU10850]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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