KEGG   ENZYME: 1.1.1.372Help
Entry
EC 1.1.1.372                Enzyme                                 

Name
D/L-glyceraldehyde reductase;
gld1 (gene name);
gaaD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
glycerol:NADP+ oxidoreductase (D/L-glyceraldehyde-forming)
Reaction(IUBMB)
(1) glycerol + NADP+ = L-glyceraldehyde + NADPH + H+ [RN:R10563];
(2) glycerol + NADP+ = D-glyceraldehyde + NADPH + H+ [RN:R01041]
Reaction(KEGG)
Substrate
glycerol [CPD:C00116];
NADP+ [CPD:C00006]
Product
L-glyceraldehyde [CPD:C02426];
NADPH [CPD:C00005];
H+ [CPD:C00080];
D-glyceraldehyde [CPD:C00577]
Comment
The enzyme takes part in a D-galacturonate degradation pathway in the fungi Aspergillus niger and Trichoderma reesei (Hypocrea jecorina). It has equal activity with D- and L-glyceraldehyde, and can also reduce glyoxal and methylglyoxal. The reaction is only observed in the direction of glyceraldehyde reduction.
History
EC 1.1.1.372 created 2014
Pathway
Pentose and glucuronate interconversions
Metabolic pathways
Orthology
K18107  
L-glyceraldehyde reductase
Genes
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ANI: 
AFM: 
AOR: 
AOR_1_462144(AO090023000264)
ANG: 
ANI_1_172094(An11g01120)
AFV: 
ACT: 
NFI: 
PCS: 
PBL: 
PBN: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
BCOM: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
GTR: 
LBC: 
MPR: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT112884(AGABI1DRAFT_112884) AGABI1DRAFT84126(AGABI1DRAFT_84126)
ABV: 
AGABI2DRAFT151116(AGABI2DRAFT_151116) AGABI2DRAFT192853(AGABI2DRAFT_192853)
CPUT: 
SLA: 
PFP: 
MGL: 
PGR: 
MLR: 
 » show all
Taxonomy
Reference
1  [PMID:16930134]
  Authors
Liepins J, Kuorelahti S, Penttila M, Richard P
  Title
Enzymes for the NADPH-dependent reduction of dihydroxyacetone and D-glyceraldehyde and L-glyceraldehyde in the mould Hypocrea jecorina.
  Journal
FEBS. J. 273 (2006) 4229-35.
  Sequence
Reference
2  [PMID:18768163]
  Authors
Martens-Uzunova ES, Schaap PJ
  Title
An evolutionary conserved d-galacturonic acid metabolic pathway operates across filamentous fungi capable of pectin degradation.
  Journal
Fungal. Genet. Biol. 45 (2008) 1449-57.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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