KEGG   ENZYME: 1.1.1.374Help
Entry
EC 1.1.1.374                Enzyme                                 

Name
UDP-N-acetylglucosamine 3-dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:NAD+ 3-oxidoreductase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + NAD+ = UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH + H+ [RN:R10785]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
NAD+ [CPD:C00003]
Product
UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose [CPD:C20849];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Methanococcus maripaludis is activated by KCl (200 mM).
History
EC 1.1.1.374 created 2014
Orthology
K18855  UDP-N-acetylglucosamine 3-dehydrogenase
Genes
DFO: Dform_01821
MMP: MMP0352
MVN: Mevan_0204
MVO: Mvol_0228
MAC: MA_4448(idh)
MBA: Mbar_A1138
MBY: MSBRM_3417
MBW: MSBRW_3585
MBAR: MSBR2_3374
MBAK: MSBR3_3343
MTHE: MSTHC_1603
MTHR: MSTHT_1686
MMET: MCMEM_0690
MPY: Mpsy_0709
RCI: RCIX1923(idhA)
MTH: MTH_875
METC: MTCT_0793
METE: tca_00840(iolX)
MST: Msp_1333
MSI: Msm_0882
MRU: mru_1747
MEB: Abm4_0457
MMIL: sm9_1833
MEYE: TL18_08545
MOL: YLM1_1201
METH: MBMB1_0357
MFC: BRM9_1907
MCUB: MCBB_0333
MFV: Mfer_1207
MKA: MK0248
PAB: PAB0775
PFU: PF0766
PFI: PFC_02985
TGA: TGAM_2151
TSI: TSIB_2031
THM: CL1_0826
TLT: OCC_01379
HBU: Hbut_1413
PYR: P186_2329
POG: Pogu_2396
NMR: Nmar_0247
NCT: NMSP_1463
NEV: NTE_02307
TAA: NMY3_00953(iolG)
NCV: NCAV_0867
NBV: T478_1203
NDV: NDEV_1854
KCR: Kcr_1479
 » show all
Taxonomy
Reference
1  [PMID:18634748]
  Authors
Namboori SC, Graham DE
  Title
Enzymatic analysis of uridine diphosphate N-acetyl-D-glucosamine.
  Journal
Anal. Biochem. 381 (2008) 94-100.
  Sequence
[mmp:MMP0352]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.374
IUBMB Enzyme Nomenclature: 1.1.1.374
ExPASy - ENZYME nomenclature database: 1.1.1.374
BRENDA, the Enzyme Database: 1.1.1.374

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