KEGG   ENZYME: 1.1.1.376Help
Entry
EC 1.1.1.376                Enzyme                                 

Name
L-arabinose 1-dehydrogenase [NAD(P)+];
L-arabino-aldose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-arabinose:NAD(P)+ 1-oxidoreductase
Reaction(IUBMB)
L-arabinose + NAD(P)+ = L-arabinono-1,4-lactone + NAD(P)H + H+ [RN:R01757 R10787]
Reaction(KEGG)
Substrate
L-arabinose [CPD:C00259];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
L-arabinono-1,4-lactone [CPD:C01114];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzymes from the bacterium Azospirillum brasilense and the archaeon Haloferax volcanii are part of the L-arabinose degradation pathway and prefer NADP+ over NAD+. In vitro the enzyme from Azospirillum brasilense shows also high catalytic efficiency with D-galactose.
History
EC 1.1.1.376 created 2014
Pathway
Ascorbate and aldarate metabolism
Orthology
K13873  
L-arabinose 1-dehydrogenase
K19660  
L-arabinose 1-dehydrogenase [NAD(P)+]
Genes
RPI: 
RPF: 
RMN: 
BTE: 
BTQ: 
BTJ: 
BTZ: 
BTD: 
BTV: 
BTHE: 
BTHM: 
BTHA: 
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BVI: 
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BCEO: 
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NMG: 
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NAT: 
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Taxonomy
Reference
1
  Authors
Novick, N.J. and Tyler, M.E.
  Title
Partial purification and properties of an L-arabinose dehydrogenase from Azospirillum brasilense.
  Journal
Can. J. Microbiol. 29 (1983) 242-246.
Reference
2  [PMID:16326697]
  Authors
Watanabe S, Kodaki T, Makino K
  Title
Cloning, expression, and characterization of bacterial L-arabinose 1-dehydrogenase involved in an alternative pathway of L-arabinose metabolism.
  Journal
J. Biol. Chem. 281 (2006) 2612-23.
  Sequence
Reference
3  [PMID:23949136]
  Authors
Johnsen U, Sutter JM, Zaiss H, Schonheit P
  Title
L-Arabinose degradation pathway in the haloarchaeon Haloferax volcanii involves a novel type of L-arabinose dehydrogenase.
  Journal
Extremophiles. 17 (2013) 897-909.
  Sequence
[hvo:HVO_B0032]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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