KEGG   ENZYME: 1.1.1.43Help
Entry
EC 1.1.1.43                 Enzyme                                 

Name
phosphogluconate 2-dehydrogenase;
6-phosphogluconic dehydrogenase;
phosphogluconate dehydrogenase;
gluconate 6-phosphate dehydrogenase;
6-phosphogluconate dehydrogenase (NAD+);
2-keto-6-phosphogluconate reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
6-phospho-D-gluconate + NAD(P)+ = 6-phospho-2-dehydro-D-gluconate + NAD(P)H + H+ [RN:R02032 R02034]
Reaction(KEGG)
Substrate
6-phospho-D-gluconate [CPD:C00345];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
6-phospho-2-dehydro-D-gluconate [CPD:C01218];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.1.1.43 created 1961
Pathway
ec00030  Pentose phosphate pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00032  phosphogluconate 2-dehydrogenase
Genes
PAE: PA2263
PAEV: N297_2336
PAEI: N296_2336
PAU: PA14_35320(kguD)
PAP: PSPA7_2977
PAG: PLES_30411
PAF: PAM18_2777
PNC: NCGM2_3273(kguD)
PAEB: NCGM1900_4267(kguD)
PDK: PADK2_13960
PAEP: PA1S_14305
PAEM: U769_13890
PAEL: T223_15535
PAEG: AI22_19550
PAEC: M802_2333
PAEO: M801_2335
PCQ: PcP3B5_34720(ghrB_4)
PPU: PP_3376(ptxD)
PPF: Pput_2382
PPT: PPS_2854
PPI: YSA_11138
PPX: T1E_5148(tkrA)
PPUH: B479_14190
PPUT: L483_13870
PPUN: PP4_27660(kguD)
PPUD: DW66_3112
PMON: X969_13660
PMOT: X970_13305
PFL: PFL_2717(ghrB1)
PPRC: PFLCHA0_c27780(ghrB2)
PPRO: PPC_2764(ghrB1)
PFO: Pfl01_2904(yiaE)
PFS: PFLU_2712
PFE: PSF113_3674(kguD)
PFC: PflA506_2981(ghrB1)
PFW: PF1751_v1c23760(ghrB)
PFB: VO64_0047
PMAN: OU5_0566
PSTT: CH92_21465
PSEM: TO66_17295
PSEC: CCOS191_2350(ghrB2)
PSOS: POS17_3330(ghrB1)
PANR: A7J50_2583
PSIL: PMA3_15845
AVN: Avin_26910(kguD)
AVL: AvCA_26910(kguD)
AVD: AvCA6_26910(kguD)
ACX: Achr_21860(kguD)
CSA: Csal_0273
HAM: HALO3070
HCO: LOKO_02347(ghrB)
REH: H16_B1813(kguD)
 » show all
Taxonomy
Reference
1  [PMID:13894458]
  Authors
FRAMPTON EW, WOOD WA.
  Title
Carbohydrate oxidation by Pseudomonas fluorescens VI. Conversion of 2-keto-6-phosphogluconate to pyruvate.
  Journal
J. Biol. Chem. 236 (1961) 2571-7.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.43
IUBMB Enzyme Nomenclature: 1.1.1.43
ExPASy - ENZYME nomenclature database: 1.1.1.43
BRENDA, the Enzyme Database: 1.1.1.43
CAS: 9001-82-5

DBGET integrated database retrieval system