KEGG   ENZYME: 1.1.1.45Help
Entry
EC 1.1.1.45                 Enzyme                                 

Name
L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-gulonate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]
Reaction(KEGG)
Substrate
L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product
3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also oxidizes other L-3-hydroxyacids.
History
EC 1.1.1.45 created 1961
Pathway
Pentose and glucuronate interconversions
Metabolic pathways
Orthology
K13247  
L-gulonate 3-dehydrogenase
Genes
HSA: 
51084(CRYL1)
PTR: 
452458(CRYL1)
PPS: 
100972837(CRYL1)
GGO: 
101150176(CRYL1)
PON: 
100171829(CRYL1)
NLE: 
100592398(CRYL1)
MCC: 
703988(CRYL1)
MCF: 
102126962(CRYL1)
CSAB: 
103248964(CRYL1)
RRO: 
104653941(CRYL1)
CJC: 
100412249(CRYL1)
SBQ: 
101053731(CRYL1)
MMU: 
68631(Cryl1)
RNO: 
290277(Cryl1)
CGE: 
100763866(Cryl1)
NGI: 
103726723(Cryl1)
HGL: 
101708457(Cryl1)
OCU: 
100009108(CRYL1)
TUP: 
102481339(CRYL1)
CFA: 
486050(CRYL1)
AML: 
100472061(CRYL1)
UMR: 
103664279(CRYL1)
FCA: 
101092816(CRYL1)
PTG: 
102950829(CRYL1)
BTA: 
281725(CRYL1)
BOM: 
102271200(CRYL1)
PHD: 
102332401(CRYL1)
CHX: 
102170708(CRYL1)
OAS: 
101118708(CRYL1)
SSC: 
396914(CRYL1)
CFR: 
102509868(CRYL1)
BACU: 
103009238(CRYL1)
LVE: 
103070582(CRYL1)
ECB: 
100054141(CRYL1)
MYB: 
102243403(CRYL1)
MYD: 
102772105(CRYL1)
PALE: 
102894030(CRYL1)
LAV: 
100659835(CRYL1)
MDO: 
100023498(CRYL1)
SHR: 
OAA: 
100089465(CRYL1)
GGA: 
418953(CRYL1)
MGP: 
100551040(CRYL1)
CJO: 
107308329(CRYL1)
APLA: 
101793734(CRYL1)
TGU: 
100232047(CRYL1)
GFR: 
102041430(CRYL1)
FAB: 
101817119(CRYL1)
PHI: 
102101871(CRYL1)
CCW: 
104690100(CRYL1)
FPG: 
101922282(CRYL1)
FCH: 
102049266(CRYL1)
CLV: 
102083838(CRYL1)
AAM: 
106500417(CRYL1)
ASN: 
102385817(CRYL1)
AMJ: 
102567690(CRYL1)
PSS: 
102463965(CRYL1)
CMY: 
102935894(CRYL1)
ACS: 
100564118(cryl1)
PBI: 
103051802(CRYL1)
GJA: 
107125996(CRYL1)
XLA: 
100036971(cryl1.L) 108709973(cryl1.S)
XTR: 
100145620(cryl1)
DRE: 
751596(cryl1)
TRU: 
101068058(cryl1)
TNG: 
MZE: 
101465841(cryl1)
OLA: 
101157739(cryl1)
XMA: 
SASA: 
100195418(cryl1)
LCM: 
102362253(CRYL1)
CMK: 
103186496(cryl1)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD11066(Dsim_GD11066) Dsimw501_GD24495(Dsim_GD24495)
DWI: 
DYA: 
Dyak_GE11007(dyak_GLEANR_10937) Dyak_GE13601(dyak_GLEANR_13797)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
406119(Cryl1)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CELE_Y71F9B.9(Y71F9B.9)
CBR: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
HMG: 
AQU: 
MBR: 
SRE: 
 » show all
Taxonomy
Reference
1
  Authors
Dworsky, P. and Hoffmann-Ostenhof, O.
  Title
L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.
  Journal
Acta Biochim. Pol. 11 (1964) 269-277.
Reference
2
  Authors
Smiley, J.D. and Ashwell, G.
  Title
Purification and properties of beta-L-hydroxy acid dehydrogenase. II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.
  Journal
J. Biol. Chem. 236 (1961) 357-364.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-51-7

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