KEGG   ENZYME: 1.1.1.48Help
Entry
EC 1.1.1.48                 Enzyme                                 
Name
D-galactose 1-dehydrogenase;
D-galactose dehydrogenase;
beta-galactose dehydrogenase (ambiguous);
NAD+-dependent D-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ [RN:R01094]
Reaction(KEGG)
Substrate
D-galactose [CPD:C00124];
NAD+ [CPD:C00003]
Product
D-galactono-1,4-lactone [CPD:C03383];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
Pathway
Galactose metabolism
Metabolic pathways
Orthology
K00035  
D-galactose 1-dehydrogenase
Genes
XCC: 
XCC0744(dgd)
XCB: 
XCA: 
XCV: 
XCP: 
XAC: 
XAC0797(dgd)
XAX: 
XAO: 
XOO: 
XOO3804(dgd)
XOM: 
XOP: 
PXO_04345
XOR: 
XOC_0862
XCI: 
XCAW_03785(dgd)
PSU: 
Psesu_0880
PST: 
PSPTO_4782(gal)
PSB: 
Psyr_4331
PSP: 
PSPPH_4371(gal)
PFE: 
PSF113_3188
PBA: 
PSEBR_a2607
CSA: 
Csal_1017
HEL: 
HELO_2796(gal)
HSE: 
Hsero_2708
MLO: 
mll0280
MCI: 
Mesci_3619
MOP: 
Mesop_4628
MAM: 
Mesau_04253
MES: 
Meso_0843
SME: 
SMc00588(gal)
SMK: 
Sinme_0954
SMQ: 
SinmeB_0783
SMX: 
SM11_chr2506(gal)
SMI: 
BN406_00892(gal)
SMEG: 
C770_GR4Chr1167
SMEL: 
SM2011_c00588(gal)
SMD: 
Smed_0768
RHI: 
NGR_c09060
SFH: 
SFHH103_00835(gal)
SFD: 
USDA257_c08790(gal)
ATU: 
Atu1113
ARA: 
Arad_1691(gal)
AVI: 
Avi_3910
AGR: 
AGROH133_05248(gal)
RET: 
RHE_CH01458(gal)
REC: 
RHECIAT_CH0001526(gal)
RLE: 
RL1574
RLT: 
Rleg2_1072
RLG: 
Rleg_1217
RTR: 
RTCIAT899_CH06205
BME: 
BMEII0355
BMI: 
BMEA_B0926
BMZ: 
BM28_B0912
BMG: 
BM590_B0910
BMW: 
BMNI_II0882
BMF: 
BAB2_0293
BMB: 
BruAb2_0292
BMC: 
BAbS19_II02780
BAA: 
BAA13334_II00689
BMS: 
BRA0941
BSI: 
BS1330_II0933
BMT: 
BSUIS_B0934
BSV: 
BSVBI22_B0932
BOV: 
BOV_A0883
BCS: 
BCAN_B0961(gal)
BSK: 
BCA52141_II1676
BMR: 
BMI_II935
OAN: 
Oant_1420
BJA: 
blr3205
BJU: 
BJ6T_65470
BRA: 
BRADO1814
BBT: 
BBta_2134
BRS: 
S23_47920
AOL: 
S58_57220
SNO: 
Snov_0117
MRD: 
Mrad2831_1330
MET: 
M446_4632
BID: 
Bind_3077
PHL: 
KKY_220
CCR: 
CC_0967
CCS: 
CCNA_01018
CAK: 
Caul_3616 Caul_3971
CSE: 
Cseg_1896 Cseg_3324
AEX: 
Astex_1898
RLI: 
RLO149_c021980(gal)
PDE: 
Pden_4245
OAT: 
OAN307_c48590(gal)
OAR: 
OA238_c48520(gal)
NPP: 
PP1Y_Mpl1273
SAL: 
Sala_0745
SPHM: 
G432_06460
SJP: 
SJA_C1-05950
AZL: 
AZL_e03690(gal)
ALI: 
AZOLI_p50383
ABS: 
AZOBR_p440166
TMO: 
TMO_a0253
 » show all
Taxonomy
Reference
1  [PMID:13462997]
  Authors
DE LEY J, DOUDOROFF M.
  Title
The metabolism of D-galactose in Pseudomonas saccharophila.
  Journal
J. Biol. Chem. 227 (1957) 745-57.
  Organism
Pseudomonas saccharophila
Reference
2  [PMID:14251301]
  Authors
HU AS, CLINE AL.
  Title
THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD.
  Journal
Biochim. Biophys. Acta. 93 (1964) 237-45.
  Organism
Pseudomonas saccharophila
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-54-0
DBGET integrated database retrieval system