KEGG   ENZYME: 1.1.1.48Help
Entry
EC 1.1.1.48                 Enzyme                                 

Name
D-galactose 1-dehydrogenase;
D-galactose dehydrogenase;
beta-galactose dehydrogenase (ambiguous);
NAD+-dependent D-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ [RN:R01094]
Reaction(KEGG)
Substrate
D-galactose [CPD:C00124];
NAD+ [CPD:C00003]
Product
D-galactono-1,4-lactone [CPD:C03383];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
History
EC 1.1.1.48 created 1961, modified 2011
Pathway
Galactose metabolism
Metabolic pathways
Orthology
K00035  
D-galactose 1-dehydrogenase
Genes
XCC: 
XCC0744(dgd)
XCB: 
XCA: 
XCP: 
XCV: 
XAC: 
XAC0797(dgd)
XCI: 
XAX: 
XAO: 
XOO: 
XOO3804(dgd)
XOM: 
XOP: 
XOR: 
XFU: 
PSU: 
PST: 
PSB: 
PSYR: 
PSP: 
PFE: 
PBA: 
PBC: 
CSA: 
HEL: 
HSE: 
MLO: 
MCI: 
MOP: 
MAM: 
MES: 
SME: 
SMK: 
SMQ: 
SMX: 
SMI: 
SMEG: 
SMEL: 
SMD: 
RHI: 
SFH: 
SFD: 
EAD: 
ATU: 
ARA: 
AVI: 
AGR: 
RET: 
REC: 
REL: 
RLE: 
RLT: 
RLG: 
RLB: 
RLU: 
RTR: 
RIR: 
RHL: 
NGL: 
BME: 
BMI: 
BMZ: 
BMG: 
BMW: 
BMF: 
BMB: 
BMC: 
BAA: 
BMS: 
BSI: 
BMT: 
BSV: 
BSF: 
BOV: 
BCS: 
BSK: 
BOL: 
BMR: 
OAN: 
BJA: 
BJU: 
BRA: 
BBT: 
BRS: 
AOL: 
SNO: 
MRD: 
MET: 
BID: 
PHL: 
CCR: 
CCS: 
CAK: 
CSE: 
AEX: 
RLI: 
PDE: 
PAMI: 
OAT: 
OAR: 
NPP: 
SAL: 
SPHM: 
SJP: 
AZL: 
ALI: 
ABS: 
TMO: 
 » show all
Taxonomy
Reference
1  [PMID:13462997]
  Authors
DE LEY J, DOUDOROFF M.
  Title
The metabolism of D-galactose in Pseudomonas saccharophila.
  Journal
J. Biol. Chem. 227 (1957) 745-57.
Reference
2  [PMID:14251301]
  Authors
HU AS, CLINE AL.
  Title
THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD.
  Journal
Biochim. Biophys. Acta. 93 (1964) 237-45.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-54-0

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