KEGG   ENZYME: 1.1.1.51Help
Entry
EC 1.1.1.51                 Enzyme                                 

Name
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
History
EC 1.1.1.51 created 1961
Pathway
ec00140  Steroid hormone biosynthesis
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04119  aldo-keto reductase family 1 member C3
K05296  3(or 17)beta-hydroxysteroid dehydrogenase
Genes
HSA: 8644(AKR1C3)
PTR: 100612718(AKR1C3)
PPS: 100971300 100986388(AKR1C3)
GGO: 101144878
PON: 100174617(AKR1C3)
NLE: 100604844(AKR1C3)
MCC: 711440(AKR1C3)
MCF: 102116465(AKR1C2) 102142023(HSD17B5) 102143072
CSAB: 103237812
RBB: 108526145 108532990
CJC: 100409025
HGL: 101702106
CFA: 497070(AKR1C3)
FCA: 100510801(AKR1C3)
PTG: 102963188
AJU: 106988139
SSC: 733634(AKR1C1)
CFR: 102511678
LVE: 103069218
ECB: 100070616
MYB: 102255491
MYD: 102751586
TMU: 101342771
OAA: 100085065
CMY: 102946053
GJA: 107108026
XLA: 100049750(LOC100490956.L) 443571(akr1c3.L)
XTR: 105946859 779627(akr1c3)
PKC: PKB_4320
SPL: Spea_2173
SHL: Shal_2144
REH: H16_B0642(h16_B0642) H16_B0649(h16_B0649)
BCT: GEM_4149
BCON: NL30_04370
BTEI: WS51_05535
BFN: OI25_4612
CTES: O987_11065
GME: Gmet_2217
SPHD: HY78_14230
SPHR: BSY17_3924
SINB: SIDU_16905
 » show all
Taxonomy
Reference
1  [PMID:14214322]
  Authors
DAHM K, BREUER H.
  Title
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 336 (1964) 63-8.
Reference
2  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J. Biol. Chem. 232 (1958) 1015-30.
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J. Biol. Chem. 218 (1956) 661-74.
Reference
4  [PMID:193845]
  Authors
Schultz RM, Groman EV, Engel LL.
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J. Biol. Chem. 252 (1977) 3775-83.
Reference
5  [PMID:13129261]
  Authors
TALALAY P, DOBSON MM.
  Title
Purification and properties of a beta-hydroxysteroid dehydrogenase.
  Journal
J. Biol. Chem. 205 (1953) 823-37.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.51
IUBMB Enzyme Nomenclature: 1.1.1.51
ExPASy - ENZYME nomenclature database: 1.1.1.51
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.51
BRENDA, the Enzyme Database: 1.1.1.51
CAS: 9015-81-0

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