KEGG   ENZYME: 1.1.1.51Help
Entry
EC 1.1.1.51                 Enzyme                                 

Name
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
History
EC 1.1.1.51 created 1961
Pathway
Steroid hormone biosynthesis
Steroid degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K04119  
aldo-keto reductase family 1 member C3
K05296  
3(or 17)beta-hydroxysteroid dehydrogenase
Genes
HSA: 
8644(AKR1C3)
PTR: 
100612718(AKR1C3)
PPS: 
100986388(AKR1C3)
GGO: 
PON: 
100174617(AKR1C3)
NLE: 
100604844(AKR1C3)
MCC: 
711440(AKR1C3)
MCF: 
102142023(HSD17B5)
SBQ: 
CFA: 
497070(AKR1C3)
FCA: 
100510801(AKR1C3)
PTG: 
102963188
AJU: 
106988139
BTA: 
100139386(20ALPHA-HSD) 100337056 107131313 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 619029 782884 785762 785996
BOM: 
102269337
BIU: 
109568087
SSC: 
733634(AKR1C1)
BACU: 
103002145 103003050
LVE: 
103069218
ECB: 
100070616
MYB: 
102255491
MYD: 
102751586
OAA: 
100085065
PSS: 
102446010
XLA: 
100049750(LOC100490956.L) 443571(akr1c3.L)
XTR: 
105946859 779627(akr1c3)
PRE: 
PCA10_43660
PPUU: 
PputUW4_01679
PKC: 
PKB_4320
PFZ: 
AV641_10575
PPSY: 
AOC04_07875
SPL: 
Spea_2173
SHL: 
Shal_2144
ZAL: 
AZF00_07095
HJA: 
BST95_16580
RIN: 
ACS15_4335 ACS15_4391
REU: 
Reut_A1545 Reut_A1552
REH: 
H16_B0642(h16_B0642) H16_B0649(h16_B0649)
CNC: 
CNE_2c05880 CNE_2c05960
CTI: 
RALTA_B0491
CBW: 
RR42_s2341
BUR: 
Bcep18194_B1514
BCT: 
GEM_4149
BCEP: 
APZ15_31395
BPYR: 
ABD05_28030
BCON: 
NL30_04370
BDF: 
WI26_20980
BTEI: 
WS51_05535
BSTL: 
BBJ41_21110
BFN: 
OI25_4612
PVE: 
UC34_06900
CTT: 
CtCNB1_1764
CTES: 
O987_11065
AZI: 
AzCIB_1461
THU: 
AC731_008840
GME: 
Gmet_2217
AEX: 
Astex_2504
NPP: 
PP1Y_Mpl5490
NRE: 
BES08_24625
SYB: 
TZ53_04155
SPHR: 
BSY17_3924
SINB: 
SIDU_16905
SPHG: 
AZE99_02220 AZE99_05050
SFLA: 
SPHFLASMR4Y_01334(benD) SPHFLASMR4Y_01377(benD) SPHFLASMR4Y_01932(benD)
ELQ: 
Ga0102493_111116
CMAN: 
A9D14_16350
PORL: 
BG023_11268
 » show all
Taxonomy
Reference
1  [PMID:14214322]
  Authors
DAHM K, BREUER H.
  Title
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 336 (1964) 63-8.
Reference
2  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J. Biol. Chem. 232 (1958) 1015-30.
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J. Biol. Chem. 218 (1956) 661-74.
Reference
4  [PMID:193845]
  Authors
Schultz RM, Groman EV, Engel LL.
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J. Biol. Chem. 252 (1977) 3775-83.
Reference
5  [PMID:13129261]
  Authors
TALALAY P, DOBSON MM.
  Title
Purification and properties of a beta-hydroxysteroid dehydrogenase.
  Journal
J. Biol. Chem. 205 (1953) 823-37.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9015-81-0
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