KEGG   ENZYME: 1.1.1.51Help
Entry
EC 1.1.1.51                 Enzyme                                 

Name
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
History
EC 1.1.1.51 created 1961
Pathway
ec00140  Steroid hormone biosynthesis
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04119  aldo-keto reductase family 1 member C3
K05296  3(or 17)beta-hydroxysteroid dehydrogenase
Genes
HSA: 8644(AKR1C3)
PTR: 100612718(AKR1C3)
PPS: 100971300 100986388(AKR1C3)
GGO: 101144878
PON: 100174617(AKR1C3)
NLE: 100604844(AKR1C3)
MCC: 711440(AKR1C3)
MCF: 102116465(AKR1C2) 102142023(HSD17B5) 102143072
CSAB: 103237812
RBB: 108526145 108532990
CJC: 100409025
SBQ: 101041594 101042225 101049957
NGI: 103725884 103725890 103746652
HGL: 101702106
CCAN: 109678869 109680482 109680990
TUP: 102478063 102478495
CFA: 497070(AKR1C3)
ORO: 101377633 101379669
FCA: 100510801(AKR1C3)
PTG: 102963188
AJU: 106988139
BTA: 100139386(20ALPHA-HSD) 100337056 107131313 282138(AKR1C4) 506594 527068 538060 617917(AKR1C3) 619029 782884 785762 785996
BOM: 102267155 102267428 102269337 102269891 102271037 102271453 102271733 102272308 102272594 102272882 102273443 102283454 102284205
BIU: 109567626 109567627 109567629 109568073 109568074 109568076 109568077 109568079 109568080 109568084 109568087
PHD: 102318654 102319004 102320281 102320641 102325285 102325641 102325997 102326595 102327306 102327680
CHX: 102176340 102176622 102177638 102186942 102187204 102187504 102187932 102188418 102188684 102188841 102189109 102189495 102190498
OAS: 101106610 101107119 101107541 101107809 101108071 101108332 101109111 101109377 101109633 101110434 101110693 105614315 106990122 443108(PGFS)
SSC: 733634(AKR1C1)
CFR: 102511678
CDK: 105091364 105105880
BACU: 103002145 103003050
LVE: 103069218
OOR: 101273575 101281536
ECB: 100070616
EPZ: 103541473 103542048
EAI: 106824649 106827241 106827468 106846834
MYB: 102255491
MYD: 102751586
LAV: 100659630 100659914 100660861
TMU: 101342771
OAA: 100085065
PSS: 102446010 102446253 102446483
CMY: 102946053
CPIC: 101940001 101940260 101940524
PVT: 110070400 110071420 110071445 110088827
GJA: 107108026
XLA: 100049750(LOC100490956.L) 443571(akr1c3.L)
XTR: 105946859 779627(akr1c3)
NPR: 108799287 108799289 108799292
PRE: PCA10_43660
PPUU: PputUW4_01679
PKC: PKB_4320
PFZ: AV641_10575
PPSY: AOC04_07875
SPL: Spea_2173
SHL: Shal_2144
ZAL: AZF00_07095
HJA: BST95_16580
RIN: ACS15_4335 ACS15_4391
REU: Reut_A1545 Reut_A1552
REH: H16_B0642(h16_B0642) H16_B0649(h16_B0649)
CNC: CNE_2c05880 CNE_2c05960
CTI: RALTA_B0491
CBW: RR42_s2341
CUH: BJN34_30930
BUR: Bcep18194_B1514
BCT: GEM_4149
BCEP: APZ15_31395
BPYR: ABD05_28030
BCON: NL30_04370
BDF: WI26_20980
BTEI: WS51_05535
BSTL: BBJ41_21110
BFN: OI25_4612
PVE: UC34_06900
CTT: CtCNB1_1764
CTES: O987_11065
AZI: AzCIB_1461
THU: AC731_008840
GME: Gmet_2217
AEX: Astex_2504
NPP: PP1Y_Mpl5490
NRE: BES08_24625
SPHJ: BSL82_07570 BSL82_14320
SPHD: HY78_14230
SYB: TZ53_04155
SPHR: BSY17_3924
SINB: SIDU_16905
SHYD: CJD35_06880
SPHG: AZE99_02220 AZE99_05050
SFLA: SPHFLASMR4Y_01334(benD) SPHFLASMR4Y_01377(benD) SPHFLASMR4Y_01932(benD)
SPHY: CHN51_03345 CHN51_18065
ELQ: Ga0102493_111116
CMAN: A9D14_16350
PORL: BG023_11268
NCB: C0V82_25770
 » show all
Taxonomy
Reference
1  [PMID:14214322]
  Authors
DAHM K, BREUER H.
  Title
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 336 (1964) 63-8.
Reference
2  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J. Biol. Chem. 232 (1958) 1015-30.
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J. Biol. Chem. 218 (1956) 661-74.
Reference
4  [PMID:193845]
  Authors
Schultz RM, Groman EV, Engel LL.
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J. Biol. Chem. 252 (1977) 3775-83.
Reference
5  [PMID:13129261]
  Authors
TALALAY P, DOBSON MM.
  Title
Purification and properties of a beta-hydroxysteroid dehydrogenase.
  Journal
J. Biol. Chem. 205 (1953) 823-37.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.51
IUBMB Enzyme Nomenclature: 1.1.1.51
ExPASy - ENZYME nomenclature database: 1.1.1.51
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.51
BRENDA, the Enzyme Database: 1.1.1.51
CAS: 9015-81-0
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