| Entry |
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| Name |
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
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| Sysname |
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
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| Reaction(IUBMB) |
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN: R01836 R01838]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
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| Pathway |
| Steroid hormone biosynthesis | | Steroid degradation | | Metabolic pathways | | Microbial metabolism in diverse environments |
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| Orthology |
| 3(or 17)beta-hydroxysteroid dehydrogenase |
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| Genes |
REU: | | REH: | | CTI: | | CNC: | | BUR: | | CTT: | | GME: | | AEX: | |
 |
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| Reference |
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| Authors |
DAHM K, BREUER H. |
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| Title |
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.] |
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| Journal |
Hoppe. Seylers. Z. Physiol. Chem. 336 (1964) 63-8. |
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| Organism |
Rattus norvegicus [GN: rno] |
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| Reference |
|
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| Authors |
LYNN WS Jr, BROWN RH. |
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| Title |
The conversion of progesterone to androgens by testes. |
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| Journal |
J. Biol. Chem. 232 (1958) 1015-30. |
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| Organism |
Cavia porcellus |
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| Reference |
|
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| Authors |
MARCUS PI, TALALAY P. |
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| Title |
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases. |
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| Journal |
J. Biol. Chem. 218 (1956) 661-74. |
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| Organism |
Pseudomonas testosteroni |
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| Reference |
|
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| Authors |
Schultz RM, Groman EV, Engel LL. |
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| Title |
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms. |
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| Journal |
J. Biol. Chem. 252 (1977) 3775-83. |
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| Organism |
Pseudomonas testosteroni |
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| Reference |
|
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| Authors |
TALALAY P, DOBSON MM. |
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| Title |
Purification and properties of a beta-hydroxysteroid dehydrogenase. |
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| Journal |
J. Biol. Chem. 205 (1953) 823-37. |
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| Organism |
Pseudomonas sp. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: CAS: 9015-81-0 |
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