KEGG   ENZYME: 1.1.1.51Help
Entry
EC 1.1.1.51                 Enzyme                                 

Name
3(or 17)beta-hydroxysteroid dehydrogenase;
beta-hydroxy steroid dehydrogenase;
17-ketoreductase;
17beta-hydroxy steroid dehydrogenase;
3beta-hydroxysteroid dehydrogenase;
3beta-hydroxy steroid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD(P)+ = androstenedione + NAD(P)H + H+ [RN:R01836 R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts on other 3beta- or 17beta-hydroxysteroids. cf. EC 1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase.
History
EC 1.1.1.51 created 1961
Pathway
Steroid hormone biosynthesis
Steroid degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K04119  
aldo-keto reductase family 1 member C3
K05296  
3(or 17)beta-hydroxysteroid dehydrogenase
Genes
HSA: 
8644(AKR1C3)
PTR: 
100612718(AKR1C3)
PPS: 
GGO: 
PON: 
100174617(AKR1C3)
NLE: 
100604844(AKR1C3)
MCC: 
711440(AKR1C3)
MCF: 
102116465(AKR1C2) 102142023(HSD17B5)
CSAB: 
CJC: 
SBQ: 
101041594 101042225
NGI: 
103725884 103725887 103725888 103725889 103725890 103746652
HGL: 
101702106
OCU: 
100352458(PGER4)
TUP: 
102478063
CFA: 
497070(AKR1C3)
FCA: 
100510801(AKR1C3)
PTG: 
102963188
BTA: 
100337056 617917(AKR1C3)
BOM: 
102267155 102267428 102269337 102269891 102271037 102271453 102271733 102272308 102272594 102272882 102273443 102283454 102284205
PHD: 
102318654 102319004 102320281 102320641 102325285 102325641 102325997 102326595 102326958 102327306 102327680
CHX: 
102176340 102176622 102177638 102186942 102187204 102187504 102187782 102187932 102188418 102188684 102188841 102189109 102189495 102190498
OAS: 
101107119 101107541 101107809 101108332 101109111 101109377 101109633 101110434 101110693 105614315 106990122 443108(PGFS)
SSC: 
100738604 733634(AKR1C1)
BACU: 
103002145 103003050
LVE: 
103069218
ECB: 
100070616
MYB: 
102255491
MYD: 
102751586
PALE: 
102889546
LAV: 
100659630 100659914 100660861
OAA: 
100085065
PSS: 
102446010 102446253 102446483
CMY: 
102946053
GJA: 
107108026
XTR: 
779627(akr1c3)
PRE: 
PCA10_43660
PPUU: 
PputUW4_01679
PKC: 
PKB_4320
REU: 
Reut_A1545 Reut_A1552
REH: 
H16_B0642(h16_B0642) H16_B0649(h16_B0649)
CNC: 
CNE_2c05880
CTI: 
RALTA_B0491
BUR: 
Bcep18194_B1514
BCT: 
GEM_4149
CTT: 
CtCNB1_1764
CTES: 
O987_11065
GME: 
Gmet_2217
AEX: 
Astex_2504
 » show all
Taxonomy
Reference
1  [PMID:14214322]
  Authors
DAHM K, BREUER H.
  Title
[PRECIPITATION OF A 17-BETA-HYDROXYSTEROID:NAD(P) OXIDOREDUCTASE FROM THE RAT ADRENAL GLAND.]
  Journal
Hoppe. Seylers. Z. Physiol. Chem. 336 (1964) 63-8.
Reference
2  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J. Biol. Chem. 232 (1958) 1015-30.
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J. Biol. Chem. 218 (1956) 661-74.
Reference
4  [PMID:193845]
  Authors
Schultz RM, Groman EV, Engel LL.
  Title
3(17)beta-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms.
  Journal
J. Biol. Chem. 252 (1977) 3775-83.
Reference
5  [PMID:13129261]
  Authors
TALALAY P, DOBSON MM.
  Title
Purification and properties of a beta-hydroxysteroid dehydrogenase.
  Journal
J. Biol. Chem. 205 (1953) 823-37.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9015-81-0
DBGET integrated database retrieval system