KEGG   ENZYME: 1.1.1.52Help
Entry
EC 1.1.1.52                 Enzyme                                 

Name
3alpha-hydroxycholanate dehydrogenase (NAD+);
alpha-hydroxy-cholanate dehydrogenase;
lithocholate:NAD+ oxidoreductase;
3alpha-hydroxycholanate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
lithocholate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
lithocholate + NAD+ = 3-oxo-5beta-cholan-24-oate + NADH + H+ [RN:R04139]
Reaction(KEGG)
Substrate
lithocholate [CPD:C03990];
NAD+ [CPD:C00003]
Product
3-oxo-5beta-cholan-24-oate [CPD:C03070];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on other 3alpha-hydroxysteroids with an acidic side-chain. cf. EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+).
History
EC 1.1.1.52 created 1961, modified 1976, modified 2016
Reference
1  [PMID:14377608]
  Authors
HAYAISHI O, SATO Y, JAKOBY WB, STOHLMAN EF.
  Title
Reversible enzymatic oxidation of bile acids.
  Journal
Arch. Biochem. 56 (1955) 554-5.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-57-3

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