KEGG   ENZYME: 1.1.1.53Help
Entry
EC 1.1.1.53                 Enzyme                                 

Name
3alpha(or 20beta)-hydroxysteroid dehydrogenase;
cortisone reductase;
(R)-20-hydroxysteroid dehydrogenase;
dehydrogenase, 20beta-hydroxy steroid;
Delta4-3-ketosteroid hydrogenase;
20beta-hydroxysteroid dehydrogenase;
3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase;
NADH-20beta-hydroxysteroid dehydrogenase;
20beta-HSD
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase
Reaction(IUBMB)
androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+ [RN:R04330]
Reaction(KEGG)
Substrate
androstan-3alpha,17beta-diol [CPD:C03852];
NAD+ [CPD:C00003]
Product
17beta-hydroxyandrostan-3-one [CPD:C03917];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The 3alpha-hydroxy group or 20beta-hydroxy group of pregnane and androstane steroids can act as donor.
History
EC 1.1.1.53 created 1961, modified 1986
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00038  3alpha(or 20beta)-hydroxysteroid dehydrogenase
Genes
VNA: PN96_21715
PSET: THL1_4166
PRW: PsycPRwf_0909
PSPG: AK823_06640
PSYG: AK825_06710
COLW: A3Q33_18725
PHA: PSHAa0891
PTN: PTRA_a1023
PNG: PNIG_a1074
ZAL: AZF00_09860
RIN: ACS15_4336(fabG3) ACS15_4362
BCEN: DM39_3414 DM39_5921(fabG3)
BTEI: WS51_05555
BHO: D560_0970
BHM: D558_0953
ODI: ODI_R3001
RLE: RL1197
BJA: bll0026
MMED: Mame_00673(fabG3)
MALG: MALG_00957
NAR: Saro_3667
SMAZ: LH19_03100
SGI: SGRAN_1043(fabG3.1) SGRAN_3272(ucpA) SGRAN_3288(fabG3)
SWI: Swit_3288
SSAN: NX02_07890
OIH: OB0329
LBR: LVIS_0330
LBH: Lbuc_0640
JDA: BW727_101599(fabG3)
MTU: Rv2002(fabG3)
MTV: RVBD_2002
MTC: MT2058
MRA: MRA_2018(fabG3-1)
MTUR: CFBS_2112(fabG4)
MTO: MTCTRI2_2036(fabG3)
MTD: UDA_2002(fabG3)
MTN: ERDMAN_2205(fabG3)
MTUC: J113_13820
MTUE: J114_10710
MTUH: I917_14135
MTUL: TBHG_01960
MTUT: HKBT1_2108(fabG3)
MTUU: HKBT2_2108(fabG3)
MTQ: HKBS1_2113(fabG3)
MBO: BQ2027_MB2025(fabG3)
MBB: BCG_2019(fabG3)
MBT: JTY_2014(fabG3)
MBM: BCGMEX_2001(fabG3)
MBX: BCGT_1815
MAF: MAF_20140(fabG3)
MCE: MCAN_20221(fabG3)
MCQ: BN44_40286(fabG)
MCV: BN43_31181(fabG)
MCX: BN42_30300(fabG)
MCZ: BN45_50280(fabG)
MMIC: RN08_2216
MPA: MAP_1739c(fabG3) MAP_3577(fabG3)
MAVD: NF84_11335
MSG: MSMEI_3435(fabG3)
MVA: Mvan_3000
MPHL: MPHLCCUG_02464(fabG3_1)
MVQ: MYVA_1698(fabG3_1) MYVA_3063
MUL: MUL_1037(fabG3)
MAB: MAB_4680c
MABB: MASS_4710
MCHE: BB28_23275
MMC: Mmcs_2711
MKM: Mkms_2755
MJL: Mjls_2741
MJD: JDM601_0150(fabG3) JDM601_3608(fabG3)
MMI: MMAR_0387(fabG3) MMAR_2981(fabG3_1)
MMAE: MMARE11_03500(fabG3) MMARE11_29030(fabG3_1)
MLI: MULP_00374(fabG3) MULP_02842(hsd)
ASD: AS9A_1016
CGT: cgR_0065
NFA: NFA_48060
NNO: NONO_c26260(fabG5) NONO_c48960 NONO_c58990(fabG2) NONO_c59020(fabG3)
RER: RER_11770
REY: O5Y_05380
ROP: ROP_15600
RHB: NY08_3965
GBR: Gbro_2728
TPR: Tpau_3804
SCO: SCO4169(SCD66.06)
SGB: WQO_14335
SHY: SHJG_8575
SALB: XNR_5139
SFI: SFUL_2902
SPRI: SPRI_4289
SLE: sle_17540(sle_17540)
SMAL: SMALA_4577
SLAU: SLA_3144
SALJ: SMD11_3946
KSK: KSE_72210
MTS: MTES_1749
ARR: ARUE_c18690(fabG2)
ACH: Achl_1690
IDO: I598_0831(fabG3)
MPH: MLP_24360
NCA: Noca_2813
NDK: I601_0636(fabG3_2) I601_3497(fabG3_3)
NDA: Ndas_4479
NAL: B005_0300(fabG3)
TCU: Tcur_3357
SRO: Sros_1990
SEN: SACE_4705
AOI: AORI_2393
PSEE: FRP1_11655
AMI: Amir_5048
KAL: KALB_3419
AHG: AHOG_04120(fabG3)
ALL: CRK59559
SAQ: Sare_2828
MIL: ML5_3168
CAI: Caci_8769
EYY: EGYY_18220(FabG)
FLN: FLA_0730
LBY: Lbys_0205
MBN: Mboo_0405
 » show all
Taxonomy
Reference
1  [PMID:718844]
  Authors
Edwards CA, Orr JC.
  Title
Comparison of the 3alpha-and 20beta-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans.
  Journal
Biochemistry. 17 (1978) 4370-6.
Reference
2  [PMID:14403761]
  Authors
HUEBENER HJ, SAHRHOLZ FG
  Title
[20 beta-Hydroxysteroid dehydrogenase. 2. Preparation and crystallization.]
  Journal
Biochem. Z. 333 (1960) 95-105.
Reference
3  [PMID:14403760]
  Authors
HUEBENER HJ, SAHRHOLZ FG, SCHMIDT-THOME J, NESEMANN G, JUNK R
  Title
[20 beta-Hydroxysteroid dehydrogenase, a new crystalline enzyme.]
  Journal
Biochim. Biophys. Acta. 35 (1959) 270-2.
Reference
4  [PMID:13549484]
  Authors
LYNN WS Jr, BROWN RH.
  Title
The conversion of progesterone to androgens by testes.
  Journal
J. Biol. Chem. 232 (1958) 1015-30.
Reference
5  [PMID:6936053]
  Authors
Strickler RC, Covey DF, Tobias B.
  Title
Study of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site.
  Journal
Biochemistry. 19 (1980) 4950-4.
Reference
6  [PMID:6928375]
  Authors
Sweet F, Samant BR.
  Title
Bifunctional enzyme activity at the same active site: study of 3 alpha and 20 beta activity by affinity alkylation of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids.
  Journal
Biochemistry. 19 (1980) 978-86.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.53
IUBMB Enzyme Nomenclature: 1.1.1.53
ExPASy - ENZYME nomenclature database: 1.1.1.53
BRENDA, the Enzyme Database: 1.1.1.53
CAS: 9028-42-6

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