KEGG   ENZYME: 1.1.1.64Help
Entry
EC 1.1.1.64                 Enzyme                                 

Name
testosterone 17beta-dehydrogenase (NADP+);
17-ketoreductase;
NADP-dependent testosterone-17beta-oxidoreductase;
testosterone 17beta-dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
17beta-hydroxysteroid:NADP+ 17-oxidoreductase
Reaction(IUBMB)
testosterone + NADP+ = androstenedione + NADPH + H+ [RN:R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
History
EC 1.1.1.64 created 1965
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K10207  testosterone 17beta-dehydrogenase (NADP+)
Genes
HSA: 3293(HSD17B3)
PTR: 742116(HSD17B3)
PPS: 100972788(HSD17B3)
GGO: 101137034(HSD17B3)
PON: 100433175(HSD17B3)
NLE: 100584015(HSD17B3)
MCC: 709843(HSD17B3)
MCF: 102126699(HSD17B3)
CSAB: 103219820(HSD17B3)
RRO: 104658189(HSD17B3)
RBB: 108529285(HSD17B3)
CJC: 100414334(HSD17B3)
SBQ: 101030368(HSD17B3)
MMU: 15487(Hsd17b3)
RNO: 117182(Hsd17b3)
CGE: 100767644(Hsd17b3)
NGI: 103751616(Hsd17b3)
HGL: 101712135(Hsd17b3)
CCAN: 109683204(Hsd17b3)
OCU: 100346075(HSD17B3)
TUP: 102477731(HSD17B3)
CFA: 100856708(HSD17B3)
AML: 100468038(HSD17B3)
UMR: 103682216(HSD17B3)
ORO: 101379154(HSD17B3)
FCA: 101085324(HSD17B3)
PTG: 102972770(HSD17B3)
AJU: 106971466(HSD17B3)
BTA: 616934(HSD17B3)
BOM: 102284785(HSD17B3)
BIU: 109562717(HSD17B3)
PHD: 102341291(HSD17B3)
CHX: 102188501(HSD17B3)
OAS: 101111157(HSD17B3)
SSC: 100513224(HSD17B3)
CFR: 102514822(HSD17B3)
CDK: 105084686(HSD17B3)
BACU: 103006772(HSD17B3)
LVE: 103087691(HSD17B3)
OOR: 101283794(HSD17B3)
ECB: 100062795(HSD17B3)
EPZ: 103556464
EAI: 106841117(HSD17B3)
MYB: 102256012(HSD17B3)
MYD: 102755784(HSD17B3)
HAI: 109371900(HSD17B3)
RSS: 109434745(HSD17B3)
PALE: 102883847(HSD17B3)
LAV: 100661701(HSD17B3)
TMU: 101353253
MDO: 100014335(HSD17B3)
SHR: 100935109(HSD17B3)
GGA: 427474(HSD17B3)
CJO: 107306280(HSD17B3)
APLA: 101797428(HSD17B3)
ACYG: 106047350(HSD17B3)
GFR: 106631948(HSD17B3)
FAB: 107604273(HSD17B3)
PMAJ: 107215831(HSD17B3)
CCW: 109145194(HSD17B3)
FPG: 101920192(HSD17B3)
FCH: 102057185(HSD17B3)
CLV: 102098536(HSD17B3)
EGZ: 104125984(HSD17B3)
AAM: 106484155(HSD17B3) 106490054
ASN: 102387576(HSD17B3)
AMJ: 102576225(HSD17B3)
PSS: 102451036(HSD17B3)
CMY: 102936343(HSD17B3)
CPIC: 101953074(HSD17B3)
ACS: 100561157(hsd17b3)
PVT: 110084176(HSD17B3)
PBI: 103062335(HSD17B3)
GJA: 107111659(HSD17B3)
XLA: 108714716(hsd17b3.L)
XTR: 101730254(hsd17b3)
NPR: 108788141(HSD17B3)
DRE: 393335(hsd17b3)
CCAR: 109095009 109102469(hsd17b3)
IPU: 108265426(hsd17b3)
AMEX: 103031519(hsd17b3)
TRU: 101070933(hsd17b3)
LCO: 104920662(hsd17b3)
NCC: 104963114(hsd17b3)
MZE: 101468772(hsd17b3)
OLA: 100125485(hsd17b3)
XMA: 102216624(hsd17b3)
PRET: 103470152(hsd17b3)
NFU: 107394092(hsd17b3)
CSEM: 103398902
LCF: 108882635
BPEC: 110167040(hsd17b3)
SASA: 106580550(DHB3) 106585149(hsd17b3)
ELS: 105014100(hsd17b3)
SFM: 108938393(hsd17b3)
LCM: 102364217(HSD17B3)
CMK: 103182831(hsd17b3)
 » show all
Taxonomy
Reference
1  [PMID:13696735]
  Authors
ENDAHL GL, KOCHAKIAN CD, HAMM D.
  Title
Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 2792-6.
Reference
2  [PMID:15436478]
  Authors
SWEAT ML, SAMUELS LT, LUMRY R.
  Title
Preparation and characterization of the enzyme which converts testosterone to androstenedione.
  Journal
J. Biol. Chem. 185 (1950) 75-84.
Reference
3  [PMID:13781425]
  Authors
VILLEE CA, SPENCER JM.
  Title
Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 3615-9.
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.64
IUBMB Enzyme Nomenclature: 1.1.1.64
ExPASy - ENZYME nomenclature database: 1.1.1.64
BRENDA, the Enzyme Database: 1.1.1.64
CAS: 9028-63-1

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