KEGG   ENZYME: 1.1.1.78Help
Entry
EC 1.1.1.78                 Enzyme                                 

Name
methylglyoxal reductase (NADH);
methylglyoxal reductase;
D-lactaldehyde dehydrogenase;
methylglyoxal reductase (NADH-dependent)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-lactaldehyde:NAD+ oxidoreductase
Reaction(IUBMB)
(R)-lactaldehyde + NAD+ = 2-oxopropanal + NADH + H+ [RN:R02527]
Reaction(KEGG)
Substrate
(R)-lactaldehyde [CPD:C00937];
NAD+ [CPD:C00003]
Product
2-oxopropanal [CPD:C00546];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This mammalian enzyme differs from the yeast enzyme, EC 1.1.1.283, methylglyoxal reductase (NADPH-dependent), by its coenzyme requirement, reaction direction, and enantiomeric preference.
History
EC 1.1.1.78 created 1972, modified 2005, modified 2013
Pathway
Pyruvate metabolism
Reference
1  [PMID:14323585]
  Authors
TING SM, MILLER ON, SELLINGER OZ.
  Title
THE METABOLISM OF LACTALDEHYDE. VII. THE OXIDATION OF D-LACTALDEHYDE IN RAT LIVER.
  Journal
Biochim. Biophys. Acta. 97 (1965) 407-15.
Reference
2  [PMID:6386056]
  Authors
Ray M, Ray S
  Title
Purification and partial characterization of a methylglyoxal reductase from goat  liver.
  Journal
Biochim. Biophys. Acta. 802 (1984) 119-27.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-16-1

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