KEGG   ENZYME: 1.1.1.8Help
Entry
EC 1.1.1.8                  Enzyme                                 
Name
glycerol-3-phosphate dehydrogenase (NAD+);
alpha-glycerol phosphate dehydrogenase (NAD+);
alpha-glycerophosphate dehydrogenase (NAD+);
glycerol 1-phosphate dehydrogenase;
glycerol phosphate dehydrogenase (NAD+);
glycerophosphate dehydrogenase (NAD+);
hydroglycerophosphate dehydrogenase;
L-alpha-glycerol phosphate dehydrogenase;
L-alpha-glycerophosphate dehydrogenase;
L-glycerol phosphate dehydrogenase;
L-glycerophosphate dehydrogenase (ambiguous);
NAD+-alpha-glycerophosphate dehydrogenase;
NAD+-dependent glycerol phosphate dehydrogenase;
NAD+-dependent glycerol-3-phosphate dehydrogenase;
NAD+-L-glycerol-3-phosphate dehydrogenase;
NAD+-linked glycerol 3-phosphate dehydrogenase;
NADH-dihydroxyacetone phosphate reductase;
glycerol-3-phosphate dehydrogenase (NAD+);
L-glycerol-3-phosphate dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase
Reaction(IUBMB)
sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+ [RN:R00842]
Reaction(KEGG)
Substrate
sn-glycerol 3-phosphate [CPD:C00093];
NAD+ [CPD:C00003]
Product
glycerone phosphate [CPD:C00111];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on propane-1,2-diol phosphate and glycerone sulfate (but with a much lower affinity).
Pathway
Glycerophospholipid metabolism
Orthology
K00006  
glycerol-3-phosphate dehydrogenase (NAD+)
Genes
HSA: 
23171(GPD1L) 2819(GPD1)
PTR: 
741054(GPD1)
PPS: 
100981359(GPD1) 100983363(GPD1L)
GGO: 
101131184(GPD1) 101153797(GPD1L)
PON: 
100172201(GPD1) 100173675(GPD1L)
MCC: 
MMU: 
14555(Gpd1) 333433(Gpd1l)
RNO: 
363159(Gpd1l) 60666(Gpd1)
CFA: 
485626(GPD1L) 607942(GPD1)
AML: 
FCA: 
101086577(GPD1) 101093135(GPD1L)
BTA: 
514456(GPD1L) 525042(GPD1)
SSC: 
100153250(GPD1) 100624347
ECB: 
100052204(GPD1) 100057124
MDO: 
100021123
SHR: 
100928054(GPD1)
OAA: 
100077586 100085954
GGA: 
420664(GPD1L) 424263(GPD1) 426881
MGP: 
100547788(GPD1L) 100550137
TGU: 
100219677(GPD1L) 100219837 100225600(GPD1)
ACS: 
100551913 100552972 100556166
XLA: 
379962(gpd1l) 399227(gpd1) 444456
XTR: 
394623(gpd1l) 448519(gpd1)
DRE: 
325181(gpd1b) 406615(gpd1c) 449663(gpd1l) 550404(gpd1a)
TRU: 
101066425 101071719(GPD-C)
OLA: 
101155171 101158855
BFO: 
BRAFLDRAFT_226348
CIN: 
100181104
SPU: 
763067
DME: 
Dmel_CG3215 Dmel_CG9042(Gpdh)
DPO: 
Dpse_GA16715
DAN: 
Dana_GF13315 Dana_GF15589(Dana_Gpdh)
DER: 
Dere_GG20063 Dere_GG25104(Dere_Gpdh)
DPE: 
Dper_GL11294 Dper_GL19044(Dper_Gpdh)
DSE: 
Dsec_GM15578 Dsec_GM18581
DSI: 
Dsim_GD23370(Dsim_Gpdh) Dsim_GD25078
DWI: 
Dwil_GK14706(Dwil_Gpdh) Dwil_GK19593
DYA: 
Dyak_GE11600 Dyak_GE25734(Dyak_Gpdh)
DGR: 
Dgri_GH11012 Dgri_GH23061
DMO: 
Dmoj_GI17532 Dmoj_GI21131
DVI: 
Dvir_GJ15413(Dvir_Gpdh) Dvir_GJ20981
AGA: 
AgaP_AGAP007593
AAG: 
AaeL_AAEL001593
CQU: 
CpipJ_CPIJ000232
AME: 
726445(Gpdh)
NVI: 
100123685(NV14099) 100123687(NV14101)
TCA: 
663884
API: 
100160658
PHU: 
Phum_PHUM174010
ISC: 
IscW_ISCW005254
CEL: 
CELE_F47G4.3(gpdh-1) CELE_K11H3.1(gpdh-2)
CBR: 
CBG09958(Cbr-gpdh-2) CBG18871(Cbr-gpdh-1)
BMY: 
Bm1_45570
TSP: 
Tsp_09858
SMM: 
Smp_030500.1
NVE: 
NEMVE_v1g156868 NEMVE_v1g211642
HMG: 
100200028
TAD: 
TRIADDRAFT_38307
AQU: 
100637681
ATH: 
AT5G40610
ALY: 
ARALYDRAFT_493921
GMX: 
100798509 100803079
MTR: 
MTR_7g032630
CSV: 
101218307
RCU: 
RCOM_0531780
POP: 
POPTR_908191
VVI: 
100261224
DOSA: 
Os01t0971600-01(Os01g0971600)
BDI: 
100833474
SBI: 
SORBI_03g047310(SORBIDRAFT_03g047310)
ZMA: 
100284124
SMO: 
SELMODRAFT_132832 SELMODRAFT_451466
PPP: 
PHYPADRAFT_186920
CRE: 
CHLREDRAFT_96789
VCN: 
VOLCADRAFT_57957
CME: 
CMD113C
SCE: 
YDL022W(GPD1) YOL059W(GPD2)
AGO: 
AGOS_ADR311C
ERC: 
Ecym_5243
KLA: 
KLLA0C04004g
LTH: 
KLTH0F06622g
PPA: 
PAS_chr2-2_0111
VPO: 
Kpol_1037p2 Kpol_1045p48
ZRO: 
ZYRO0A05390g
CGR: 
CAGL0C05137g CAGL0K01683g
NCS: 
NCAS_0C03620(NCAS0C03620) NCAS_0I02050(NCAS0I02050)
NDI: 
NDAI_0A06640(NDAI0A06640) NDAI_0G02970(NDAI0G02970)
TPF: 
TPHA_0H00810(TPHA0H00810) TPHA_0P00620(TPHA0P00620)
TBL: 
TBLA_0B01610(TBLA0B01610) TBLA_0F00800(TBLA0F00800)
TDL: 
TDEL_0D04540(TDEL0D04540)
KAF: 
KAFR_0C01000(KAFR0C01000) KAFR_0F02240(KAFR0F02240)
DHA: 
DEHA2E08140g DEHA2F09372g
PIC: 
PICST_83071(GPD2) PICST_90446(GPD1)
PGU: 
PGUG_01519 PGUG_05498
LEL: 
LELG_02389 LELG_04817
CAL: 
CaO19.1756(GPD1) CaO19.691(GPD2) CaO19.8310(GPD2) CaO19.9325(GPD1)
CTP: 
CTRG_02011 CTRG_02898
CDU: 
CD36_24300(GPD1) CD36_62130
COT: 
CORT_0C06540 CORT_0F02760
YLI: 
YALI0B02948g
CLU: 
CLUG_03347 CLUG_05143
NCR: 
NCU00742
SMP: 
SMAC_01427
PAN: 
PODANSg09885
TTT: 
THITE_2122377
MTM: 
MYCTH_2313529
MGR: 
MGG_00067
FGR: 
FG05023.1
NHE: 
NECHADRAFT_76134
VAL: 
VDBG_05053
SSL: 
SS1G_12794
BFU: 
BC1G_05277
ANI: 
AN0351.2 AN6792.2
NFI: 
NFIA_022500 NFIA_083910
AFM: 
AFUA_1G02150 AFUA_2G08250
AOR: 
AOR_1_1486054(AO090011000879) AOR_1_1546174(AO090005000883)
ANG: 
ANI_1_1768134(An15g07390) ANI_1_786014(An01g06110)
AFV: 
AFLA_046760 AFLA_081330
ACT: 
ACLA_032280 ACLA_080090
PCS: 
Pc20g06370 Pc22g22110
CIM: 
CIMG_09984
CPW: 
CPC735_011590
PBL: 
PAAG_06099
URE: 
UREG_06029
ABE: 
ARB_07180
TVE: 
TRV_07706
AJE: 
HCAG_03267
PNO: 
SNOG_03768
PTE: 
PTT_06868
TML: 
GSTUM_00004115001
SPO: 
SPAC23D3.04c(gpd2) SPBC215.05(gpd1)
CNE: 
CNA01100 CNC02480
CNB: 
CNBA1070 CNBC4750
CGI: 
CGB_B1330C CGB_C3570W
MPR: 
MPER_10941
SCM: 
SCHCODRAFT_54510
UMA: 
UM00555.1
MGL: 
MGL_2451
ECU: 
ECU05_0270
EIN: 
Eint_050240
EHE: 
EHEL_050300
NCE: 
NCER_101278 NCER_102351
PFA: 
PF11_0157 PFL0780w
PFD: 
PFDG_02150
PFH: 
PFHG_03289 PFHG_04100
PYO: 
PY00789 PY05585
PCB: 
PC000289.03.0
PBE: 
PB000629.01.0 PB001193.02.0
PKN: 
PKH_091190 PKH_143330
PVX: 
PVX_091380 PVX_123490
PCY: 
PCYB_092100 PCYB_144260
TAN: 
TA21330
TPV: 
TP01_0302
BBO: 
BBOV_IV004480(23.m06005)
CPV: 
cgd2_210
CHO: 
Chro.20028
TGO: 
TGME49_010260 TGME49_107570
TBR: 
Tb927.8.3530(Tb08.28L1.740)
LMA: 
LMJF_10_0510(GPD)
LIF: 
LINJ_10_0560(GPD)
LDO: 
LDBPK_100560
LMI: 
LMXM_10_0510
LBZ: 
LBRM_10_0640(GPD)
TVA: 
TVAG_230610 TVAG_382880
PTI: 
PHATR_36821
TPS: 
THAPSDRAFT_260786
PIF: 
PITG_04065
 » show all
Taxonomy
Reference
1
  Authors
Baranowski, T.
  Title
alpha-Glycerophosphate dehydrogenase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 85-96.
Reference
2  [PMID:4307630]
  Authors
Brosemer RW, Kuhn RW.
  Title
Comparative structural properties of honeybee and rabbit alpha-glycerophosphate dehydrogenases.
  Journal
Biochemistry. 8 (1969) 2095-105.
  Organism
Apis mellifera [GN:ame], Oryctolagus cuniculus
Reference
3  [PMID:4340553]
  Authors
O'Brien SJ, MacIntyre RJ.
  Title
The  -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects.
  Journal
Biochem. Genet. 7 (1972) 141-61.
  Organism
Drosophila melanogaster [GN:dme]
Reference
4  [PMID:4200180]
  Authors
Warkentin DL, Fondy TP.
  Title
Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme.
  Journal
Eur. J. Biochem. 36 (1973) 97-109.
  Organism
Oryctolagus cuniculus
Reference
5  [PMID:1499720]
  Authors
Albertyn J, van Tonder A, Prior BA.
  Title
Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae.
  Journal
FEBS. Lett. 308 (1992) 130-2.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
6  [PMID:7671141]
  Authors
Koekemoer TC, Litthauer D, Oelofsen W.
  Title
Isolation and characterization of adipose tissue glycerol-3-phosphate dehydrogenase.
  Journal
Int. J. Biochem. Cell. Biol. 27 (1995) 625-32.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9075-65-4
DBGET integrated database retrieval system