KEGG   ENZYME: 1.1.1.84Help
Entry
EC 1.1.1.84                 Enzyme                                 

Name
dimethylmalate dehydrogenase;
beta,beta-dimethylmalate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(R)-3,3-dimethylmalate + NAD+ = 3-methyl-2-oxobutanoate + CO2 + NADH [RN:R01211]
Reaction(KEGG)
Substrate
(R)-3,3-dimethylmalate [CPD:C01088];
NAD+ [CPD:C00003]
Product
3-methyl-2-oxobutanoate [CPD:C00141];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
Requires K+ or NH4+ and Mn2+ or Co2+; also acts on (R)-malate.
History
EC 1.1.1.84 created 1972
Pathway
Pantothenate and CoA biosynthesis
Reference
1  [PMID:4287371]
  Authors
Magee PT, Snell EE.
  Title
The bacterial degradation of pantothenic acid. IV. Enzymatic conversion of aldopantoate to alpha-ketoisovalerate.
  Journal
Biochemistry. 5 (1966) 409-16.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-21-8

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