KEGG   ENZYME: 1.1.1.92Help
Entry
EC 1.1.1.92                 Enzyme                                 

Name
oxaloglycolate reductase (decarboxylating)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-glycerate:NAD(P)+ oxidoreductase (carboxylating)
Reaction(IUBMB)
D-glycerate + NAD(P)+ + CO2 = 2-hydroxy-3-oxosuccinate + NAD(P)H + 2 H+ [RN:R01749 R01750]
Reaction(KEGG)
Substrate
D-glycerate [CPD:C00258];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
CO2 [CPD:C00011]
Product
2-hydroxy-3-oxosuccinate [CPD:C03459];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also reduces hydroxypyruvate to D-glycerate and glyoxylate to glycolate.
History
EC 1.1.1.92 created 1972
Pathway
Glyoxylate and dicarboxylate metabolism
Reference
1  [PMID:4385076]
  Authors
Kohn LD, Jakoby WB.
  Title
Tartaric acid metabolism. VI. Crystalline oxaloglycolate reductive decarboxylase.
  Journal
J. Biol. Chem. 243 (1968) 2486-93.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-28-5

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