KEGG   ENZYME: 1.1.1.96Help
Entry
EC 1.1.1.96                 Enzyme                                 

Name
diiodophenylpyruvate reductase;
aromatic alpha-keto acid;
KAR;
2-oxo acid reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase
Reaction(IUBMB)
3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H+ [RN:R03431]
Reaction(KEGG)
Substrate
3-(3,5-diiodo-4-hydroxyphenyl)lactate [CPD:C04367];
NAD+ [CPD:C00003]
Product
3-(3,5-diiodo-4-hydroxyphenyl)pyruvate [CPD:C01244];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Substrates contain an aromatic ring with a pyruvate side chain. The most active substrates are halogenated derivatives. Compounds with hydroxy or amino groups in the 3 or 5 position are inactive.
History
EC 1.1.1.96 created 1972
Reference
1  [PMID:5935348]
  Authors
Zannoni VG, Weber WW.
  Title
Isolation and properties of aromatic alpha-keto acid reductase.
  Journal
J. Biol. Chem. 241 (1966) 1340-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-31-0

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