KEGG   ENZYME: 1.1.3.39Help
Entry
EC 1.1.3.39                 Enzyme                                 

Name
nucleoside oxidase (H2O2-forming)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
nucleoside:oxygen 5'-oxidoreductase (H2O2-forming)
Reaction(IUBMB)
adenosine + 2 O2 + H2O = 9-riburonosyladenine + 2 H2O2 (overall reaction) [RN:R05695];
(1a) adenosine + O2 = 5'-dehydroadenosine + H2O2 [RN:R05696];
(1b) 5'-dehydroadenosine + O2 + H2O = 9-riburonosyladenine + H2O2 [RN:R05697]
Reaction(KEGG)
Substrate
adenosine [CPD:C00212];
O2 [CPD:C00007];
H2O [CPD:C00001];
5'-dehydroadenosine [CPD:C11500]
Product
9-riburonosyladenine [CPD:C11501];
H2O2 [CPD:C00027];
5'-dehydroadenosine [CPD:C11500]
Comment
A heme-containing flavoprotein (FAD). Other purine and pyrimidine nucleosides (as well as 2'-deoxynucleosides and arabinosides) are substrates, but ribose and nucleotides are not substrates. The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction. This enzyme differs from EC 1.1.3.28, nucleoside oxidase, as it produces hydrogen peroxide rather than water.
History
EC 1.1.3.39 created 2001
Reference
1  [PMID:16535726]
  Authors
Koga S, Ogawa J, Cheng L, Choi Y, Yamada H, Shimizu S.
  Title
Nucleoside Oxidase, a Hydrogen Peroxide-Forming Oxidase, from Flavobacterium meningosepticum.
  Journal
Appl. Environ. Microbiol. 63 (1997) 4282-4286.
  Organism
Flavobacterium meningosepticum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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