KEGG   ENZYME: 1.1.3.40Help
Entry
EC 1.1.3.40                 Enzyme                                 

Name
D-mannitol oxidase;
mannitol oxidase;
D-arabitol oxidase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
mannitol:oxygen oxidoreductase (cyclizing)
Reaction(IUBMB)
mannitol + O2 = mannose + H2O2 [RN:R05698]
Reaction(KEGG)
Substrate
mannitol [CPD:C00392];
O2 [CPD:C00007]
Product
mannose [CPD:C00159];
H2O2 [CPD:C00027]
Comment
Also catalyses the oxidation of D-arabinitol and, to a lesser extent, D-glucitol (sorbitol), whereas L-arabinitol is not a good substrate. The enzyme from the snails Helix aspersa and Arion ater is found in a specialised tubular organelle that has been termed the mannosome.
History
EC 1.1.3.40 created 2001
Reference
1  [PMID:3519307]
  Authors
Vorhaben JE, Smith DD Jr, Campbell JW.
  Title
Mannitol oxidase: partial purification and characterization of the membrane-bound enzyme from the snail Helix aspersa.
  Journal
Int. J. Biochem. 18 (1986) 337-44.
Reference
2
  Authors
Large, A.T., Jones, C.J.P. and Connock, M.J.
  Title
The association of mannitol oxidase with a distinct organelle in the digestive gland of the terrestrial slug Arion ater.
  Journal
Protoplasma 175 (1993) 93-101.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
73562-29-5

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