KEGG   ENZYME: 1.1.3.42Help
Entry
EC 1.1.3.42                 Enzyme                                 

Name
prosolanapyrone-II oxidase;
Sol5 (ambiguous);
SPS (ambiguous);
solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cycloisomerase);
prosolanapyrone II oxidase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
prosolanapyrone-II:oxygen 3'-oxidoreductase
Reaction(IUBMB)
prosolanapyrone II + O2 = prosolanapyrone III + H2O2 [RN:R09807]
Reaction(KEGG)
Substrate
prosolanapyrone II [CPD:C19933];
O2 [CPD:C00007]
Product
prosolanapyrone III [CPD:C19934];
H2O2 [CPD:C00027]
Comment
The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone by some fungi. The bifunctional enzyme catalyses the oxidation of prosolanapyrone II and the subsequent Diels Alder cycloisomerization of the product prosolanapyrone III to (-)-solanapyrone A (cf. EC 5.5.1.20, prosolanapyrone III cycloisomerase).
History
EC 1.1.3.42 created 2011
Reference
1  [PMID:20486243]
  Authors
Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, Ebizuka Y, Fujii I
  Title
Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide  synthase encoded in a biosynthetic gene cluster from Alternaria solani.
  Journal
Chembiochem. 11 (2010) 1245-52.
  Organism
Alternaria solani
  Sequence
[up:D7UQ40]
Reference
2  [PMID:9659400]
  Authors
Katayama K, Kobayashi T, Oikawa H, Honma M, Ichihara A
  Title
Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction.
  Journal
Biochim. Biophys. Acta. 1384 (1998) 387-95.
  Organism
Alternaria solani
  Sequence
[up:D7UQ40]
Reference
3  [PMID:18256508]
  Authors
Katayama K, Kobayashi T, Chijimatsu M, Ichihara A, Oikawa H
  Title
Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani.
  Journal
Biosci. Biotechnol. Biochem. 72 (2008) 604-7.
  Organism
Alternaria solani
  Sequence
[up:D7UQ40]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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