paromamine 6'-oxidase;
btrQ (gene name);
neoG (gene name);
kanI (gene name);
tacB (gene name);
neoQ (obsolete gene name)

Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor

paromamine:oxygen 6'-oxidoreductase

paromamine + O2 = 6'-dehydroparomamine + H2O2 [RN:R08896]

R08896

paromamine [CPD:C01743];
O2 [CPD:C00007]

Contains FAD. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Works in combination with EC 2.6.1.93, neamine transaminase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase.

1  [PMID:17206729]

Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB.

Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.

Chembiochem. 8 (2007) 283-8.

2  [PMID:18408324]

Yu Y, Hou X, Ni X, Xia H

Biosynthesis of 3'-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption.

J. Antibiot. (Tokyo). 61 (2008) 63-9.

3  [PMID:21689223]

Clausnitzer D, Piepersberg W, Wehmeier UF

The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin.

J. Appl. Microbiol. 111 (2011) 642-51.