KEGG   ENZYME: 1.1.3.43Help
Entry
EC 1.1.3.43                 Enzyme                                 

Name
paromamine 6'-oxidase;
btrQ (gene name);
neoG (gene name);
kanI (gene name);
tacB (gene name);
neoQ (obsolete gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
paromamine:oxygen 6'-oxidoreductase
Reaction(IUBMB)
paromamine + O2 = 6'-dehydroparomamine + H2O2 [RN:R08896]
Reaction(KEGG)
Substrate
paromamine [CPD:C01743];
O2 [CPD:C00007]
Product
6'-dehydroparomamine [CPD:C17583];
H2O2 [CPD:C00027]
Comment
Contains FAD. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Works in combination with EC 2.6.1.93, neamine transaminase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase.
History
EC 1.1.3.43 created 2012
Pathway
Butirosin and neomycin biosynthesis
Biosynthesis of secondary metabolites
Orthology
K13552  
paromamine 6'-oxidase / 6'''-hydroxyneomycin C oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase
Reference
1  [PMID:17206729]
  Authors
Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB.
  Title
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.
  Journal
Chembiochem. 8 (2007) 283-8.
  Sequence
[up:Q53U15]
Reference
2  [PMID:18408324]
  Authors
Yu Y, Hou X, Ni X, Xia H
  Title
Biosynthesis of 3'-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption.
  Journal
J. Antibiot. (Tokyo). 61 (2008) 63-9.
Reference
3  [PMID:21689223]
  Authors
Clausnitzer D, Piepersberg W, Wehmeier UF
  Title
The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin.
  Journal
J. Appl. Microbiol. 111 (2011) 642-51.
  Sequence
[up:Q53U15]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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