KEGG   ENZYME: 1.1.3.44Help
Entry
EC 1.1.3.44                 Enzyme                                 

Name
6'''-hydroxyneomycin C oxidase;
neoG (gene name);
neoQ (obsolete gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
6'''-deamino-6'''-hydroxyneomycin C:oxygen 6'''-oxidoreductase
Reaction(IUBMB)
6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2 [RN:R08902]
Reaction(KEGG)
Substrate
6'''-deamino-6'''-hydroxyneomycin C [CPD:C17588];
O2 [CPD:C00007]
Product
6'''-deamino-6'''-oxoneomycin C [CPD:C17589];
H2O2 [CPD:C00027]
Comment
Contains FAD. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 2.6.1.95, neomycin C transaminase, to replace the 6'''-hydroxy group of 6'''-hydroxyneomycin C with an amino group.
Also catalyses EC 1.1.3.43, paromamine 6'-oxidase.
History
EC 1.1.3.44 created 2012
Pathway
Butirosin and neomycin biosynthesis
Biosynthesis of secondary metabolites
Orthology
K13552  
paromamine 6'-oxidase / 6'''-hydroxyneomycin C oxidase / 2'-deamino-2'-hydroxyparomamine 6'-oxidase
Reference
1  [PMID:17206729]
  Authors
Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB.
  Title
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin.
  Journal
Chembiochem. 8 (2007) 283-8.
  Sequence
[up:Q53U15]
Reference
2  [PMID:21689223]
  Authors
Clausnitzer D, Piepersberg W, Wehmeier UF
  Title
The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin.
  Journal
J. Appl. Microbiol. 111 (2011) 642-51.
  Sequence
[up:Q53U15]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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