KEGG   ENZYME: 1.1.4.1Help
Entry
EC 1.1.4.1                  Enzyme                                 

Name
vitamin-K-epoxide reductase (warfarin-sensitive)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase
Reaction(IUBMB)
2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol [RN:R03511]
Reaction(KEGG)
R03511;
(other) R03645 R09992
Show
Substrate
2-methyl-3-phytyl-1,4-naphthoquinone [CPD:C02059];
oxidized dithiothreitol [CPD:C01119]
Product
2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone [CPD:C05849];
1,4-dithiothreitol [CPD:C00265]
Comment
In the reverse reaction, vitamin K 2,3-epoxide is reduced to vitamin K and possibly to vitamin K hydroquinone by 1,4-dithiothreitol, which is oxidized to a disulfide; some other dithiols and 4-butanethiol can also act. Inhibited strongly by warfarin [cf. EC 1.1.4.2 vitamin-K-epoxide reductase (warfarin-insensitive)].
History
EC 1.1.4.1 created 1989
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Biosynthesis of secondary metabolites
Orthology
K05357  
vitamin-K-epoxide reductase (warfarin-sensitive)
Genes
HSA: 
79001(VKORC1)
PTR: 
100610370(VKORC1)
PPS: 
100989746(VKORC1)
GGO: 
PON: 
100434981(VKORC1)
MCC: 
MMU: 
27973(Vkorc1)
RNO: 
309004(Vkorc1)
CGE: 
100755703(Vkorc1)
HGL: 
101712530(Vkorc1)
TUP: 
102489609(VKORC1)
CFA: 
479775(VKORC1)
AML: 
FCA: 
101089669(VKORC1)
PTG: 
102964464(VKORC1)
BTA: 
445422(VKORC1)
BOM: 
102273264(VKORC1)
PHD: 
102327090(VKORC1)
CHX: 
102171296(VKORC1)
SSC: 
100522924(VKORC1)
CFR: 
102515335(VKORC1)
BACU: 
103001696(VKORC1)
LVE: 
103077074(VKORC1)
ECB: 
100063360(VKORC1)
MYB: 
MYD: 
102771765(VKORC1)
PALE: 
102886750(VKORC1)
MDO: 
100019247(VKORC1)
SHR: 
100914533(VKORC1)
OAA: 
100085063(VKORC1)
GGA: 
404205(VKORC1)
AMJ: 
MZE: 
OLA: 
XMA: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
NVI: 
BMOR: 
API: 
PHU: 
ISC: 
LOA: 
NVE: 
TAD: 
TGO: 
EHX: 
 » show all
Taxonomy
Reference
1  [PMID:6733086]
  Authors
Lee JJ, Fasco MJ.
  Title
Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide.
  Journal
Biochemistry. 23 (1984) 2246-52.
Reference
2  [PMID:3857611]
  Authors
Mukharji I, Silverman RB.
  Title
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 82 (1985) 2713-7.
Reference
3  [PMID:646989]
  Authors
Whitlon DS, Sadowski JA, Suttie JW.
  Title
Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition.
  Journal
Biochemistry. 17 (1978) 1371-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
55963-40-1

DBGET integrated database retrieval system