KEGG   ENZYME: 1.1.5.10Help
Entry
EC 1.1.5.10                 Enzyme                                 

Name
D-2-hydroxyacid dehydrogenase (quinone);
(R)-2-hydroxy acid dehydrogenase;
(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase;
D-lactate dehydrogenase (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
(R)-2-hydroxyacid:quinone oxidoreductase
Reaction(IUBMB)
(R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol [RN:R10625]
Reaction(KEGG)
Substrate
(R)-2-hydroxyacid [CPD:C02489];
quinone [CPD:C15602]
Product
2-oxo acid [CPD:C00161];
quinol [CPD:C15603]
Comment
The enzyme from mammalian kidney contains one mole of FAD per mole of enzyme.(R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors.
History
EC 1.1.5.10 created 2014
Reference
1  [PMID:13839714]
  Authors
TUBBS PK, GREVILLE GD.
  Title
Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria.
  Journal
Biochim. Biophys. Acta. 34 (1959) 290-1.
Reference
2  [PMID:13922962]
  Authors
TUBBS PK, GREVILLE GD
  Title
The oxidation of D-alpha-hydroxy acids in animal tissues.
  Journal
Biochem. J. 81 (1961) 104-14.
Reference
3  [PMID:5359443]
  Authors
Cammack R
  Title
Assay, purification and properties of mammalian D-2-hydroxy acid dehydrogenase.
  Journal
Biochem. J. 115 (1969) 55-64.
Reference
4  [PMID:236454]
  Authors
Cammack R
  Title
D-2-hydroxy acid dehydrogenase from animal tissue.
  Journal
Methods. Enzymol. 41 (1975) 323-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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