KEGG   ENZYME: 1.1.98.5Help
Entry
EC 1.1.98.5                 Enzyme                                 

Name
secondary-alcohol dehydrogenase (coenzyme-F420);
F420-dependent alcohol dehydrogenase;
secondary alcohol:F420 oxidoreductase;
F420-dependent secondary alcohol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
secondary-alcohol:coenzyme F420 oxidoreductase
Reaction(IUBMB)
R-CHOH-R' + oxidized coenzyme F420 = R-CO-R' + reduced coenzyme F420 [RN:R10574]
Reaction(KEGG)
Substrate
R-CHOH-R' [CPD:C01612];
oxidized coenzyme F420 [CPD:C00876]
Product
R-CO-R' [CPD:C01450];
reduced coenzyme F420 [CPD:C01080]
Comment
The enzyme isolated from the methanogenic archaea Methanogenium liminatans catalyses the reversible oxidation of various secondary and cyclic alcohols to the corresponding ketones.
History
EC 1.1.98.5 created 2013
Reference
1  [PMID:1879431]
  Authors
Bleicher K, Winter J
  Title
Purification and properties of F420- and NADP(+)-dependent alcohol dehydrogenases of Methanogenium liminatans and Methanobacterium palustre, specific for secondary alcohols.
  Journal
Eur. J. Biochem. 200 (1991) 43-51.
Reference
2  [PMID:15016352]
  Authors
Aufhammer SW, Warkentin E, Berk H, Shima S, Thauer RK, Ermler U
  Title
Coenzyme binding in F420-dependent secondary alcohol dehydrogenase, a member of the bacterial luciferase family.
  Journal
Structure. 12 (2004) 361-70.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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