KEGG   ENZYME: 1.1.99.2Help
Entry
EC 1.1.99.2                 Enzyme                                 
Name
2-hydroxyglutarate dehydrogenase;
alpha-ketoglutarate reductase;
alpha-hydroxyglutarate dehydrogenase;
L-alpha-hydroxyglutarate dehydrogenase;
hydroxyglutaric dehydrogenase;
alpha-hydroxyglutarate oxidoreductase;
L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase;
alpha-hydroxyglutarate dehydrogenase (NAD+ specific);
(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other acceptors
BRITE hierarchy
Sysname
(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Reaction(IUBMB)
(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor [RN:R00298]
Reaction(KEGG)
Substrate
(S)-2-hydroxyglutarate [CPD:C03196];
acceptor [CPD:C00028]
Product
2-oxoglutarate [CPD:C00026];
reduced acceptor [CPD:C00030]
Pathway
Butanoate metabolism
Orthology
K00109  
2-hydroxyglutarate dehydrogenase
Genes
HSA: 
79944(L2HGDH)
PTR: 
452898(L2HGDH)
PPS: 
100978899(L2HGDH)
GGO: 
101139276(L2HGDH)
PON: 
100172827(L2HGDH)
MCC: 
705721(L2HGDH)
MMU: 
217666(L2hgdh)
RNO: 
314196(L2hgdh)
CFA: 
480316(L2HGDH)
AML: 
FCA: 
101094353(L2HGDH)
BTA: 
514230(L2HGDH)
SSC: 
100152180(L2HGDH)
ECB: 
100066314
MDO: 
100018728
SHR: 
100933496
OAA: 
100084662
GGA: 
423573(L2HGDH)
MGP: 
100540849
TGU: 
100220092(L2HGDH)
ACS: 
100563174
XTR: 
100145085(l2hgdh)
DRE: 
566872(l2hgdh)
TRU: 
101061325
OLA: 
101160274
BFO: 
BRAFLDRAFT_125835
CIN: 
100184325
SPU: 
578357
DME: 
Dmel_CG10639
DPO: 
Dpse_GA10459
DAN: 
Dana_GF14644
DER: 
Dere_GG21668
DPE: 
Dper_GL19622
DSE: 
Dsec_GM17047
DSI: 
Dsim_GD21794
DWI: 
Dwil_GK24330
DYA: 
Dyak_GE12689
DGR: 
Dgri_GH11599
DMO: 
Dmoj_GI17168
DVI: 
Dvir_GJ17673
AGA: 
AgaP_AGAP007868
CQU: 
CpipJ_CPIJ010904
AME: 
410999
NVI: 
100115746(NV14728)
TCA: 
663434
API: 
100161579
PHU: 
Phum_PHUM349820
ISC: 
IscW_ISCW017395
CEL: 
CELE_Y45G12B.3(Y45G12B.3)
CBR: 
CBG06643
BMY: 
Bm1_52090
TSP: 
Tsp_09673
SMM: 
Smp_050080
NVE: 
NEMVE_v1g172254
TAD: 
TRIADDRAFT_51164
AQU: 
100634553
SMO: 
SELMODRAFT_166561 SELMODRAFT_88360
PPP: 
PHYPADRAFT_124552
MBR: 
MONBRDRAFT_14006 MONBRDRAFT_27529
DDI: 
DDB_G0267656
DPP: 
DICPUDRAFT_33881
TRO: 
trd_0887
TTR: 
Tter_2365
 » show all
Taxonomy
Reference
1
  Authors
Weil-Malherbe, H.
  Title
The oxidation of l(-)alpha-hydroxyglutaric acid in animal tissues.
  Journal
Biochem. J. 31 (1937) 2080-2094.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-80-2
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