KEGG   ENZYME: 1.1.99.24Help
Entry
EC 1.1.99.24                Enzyme                                 

Name
hydroxyacid-oxoacid transhydrogenase;
transhydrogenase, hydroxy acid-oxo acid
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase
Reaction(IUBMB)
(S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate [RN:R03225]
Reaction(KEGG)
Substrate
(S)-3-hydroxybutanoate [CPD:C03197];
2-oxoglutarate [CPD:C00026]
Product
acetoacetate [CPD:C00164];
(R)-2-hydroxyglutarate [CPD:C01087]
Comment
4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as donors; 4-oxobutanoate can also act as acceptor.
History
EC 1.1.99.24 created 1992
Orthology
K11173  hydroxyacid-oxoacid transhydrogenase
Genes
HSA: 137872(ADHFE1)
PTR: 472781(ADHFE1)
PPS: 100989227(ADHFE1)
GGO: 101130649(ADHFE1)
PON: 100189822(ADHFE1)
NLE: 100607633(ADHFE1)
MCC: 703118(ADHFE1)
MCF: 102139828(ADHFE1)
CSAB: 103236903(ADHFE1)
RRO: 104668796(ADHFE1)
RBB: 108544913(ADHFE1)
CJC: 100392867(ADHFE1)
SBQ: 101033363(ADHFE1)
MMU: 76187(Adhfe1)
RNO: 362474(Adhfe1)
CGE: 100764101(Adhfe1)
NGI: 103751369(Adhfe1)
HGL: 101715530(Adhfe1)
CCAN: 109683108(Adhfe1)
OCU: 100344305(ADHFE1)
TUP: 102492702(ADHFE1)
CFA: 477899(ADHFE1)
AML: 100474620(ADHFE1)
UMR: 103677520(ADHFE1)
ORO: 101365407(ADHFE1)
FCA: 101088980(ADHFE1)
PTG: 102966071(ADHFE1)
AJU: 106979767(ADHFE1)
BTA: 507711(ADHFE1)
BOM: 102272942(ADHFE1)
BIU: 109568623(ADHFE1)
PHD: 102328630(ADHFE1)
CHX: 102171531(ADHFE1)
OAS: 101113943(ADHFE1)
SSC: 100521620(ADHFE1)
CFR: 102512747(ADHFE1)
CDK: 105095646(ADHFE1)
BACU: 103002395(ADHFE1)
LVE: 103081097(ADHFE1)
OOR: 101269318(ADHFE1)
ECB: 100063782(ADHFE1)
EPZ: 103555251(ADHFE1)
EAI: 106829414(ADHFE1)
MYB: 102251413(ADHFE1)
MYD: 102753736(ADHFE1)
HAI: 109376633(ADHFE1)
RSS: 109444058(ADHFE1)
PALE: 102888458(ADHFE1)
LAV: 100674318(ADHFE1)
TMU: 101359091
MDO: 100029272(ADHFE1)
SHR: 100918954(ADHFE1)
OAA: 100080980(ADHFE1)
GGA: 426446(ADHFE1)
MGP: 100542368(ADHFE1)
CJO: 107310256(ADHFE1)
APLA: 101803233(ADHFE1)
ACYG: 106030646(ADHFE1)
TGU: 100222045(ADHFE1)
GFR: 102041914(ADHFE1)
FAB: 101812813(ADHFE1)
PHI: 102114159(ADHFE1)
PMAJ: 107200386(ADHFE1)
CCW: 104692841(ADHFE1)
FPG: 101913680(ADHFE1)
FCH: 102059247(ADHFE1)
CLV: 102087461(ADHFE1)
EGZ: 104122034(ADHFE1)
AAM: 106484593(ADHFE1)
ASN: 102374701(ADHFE1)
AMJ: 102575665(ADHFE1)
PSS: 102449707(ADHFE1)
CMY: 102942629(ADHFE1)
CPIC: 101952555(ADHFE1)
ACS: 100553506(adhfe1)
PVT: 110089189(ADHFE1)
PBI: 103048754(ADHFE1)
GJA: 107108521(ADHFE1)
XLA: 100158357(adhfe1.S)
XTR: 394891(adhfe1)
NPR: 108785185(ADHFE1)
DRE: 404618(adhfe1)
SRX: 107721743(adhfe1)
SANH: 107690131(adhfe1)
SGH: 107567008(adhfe1)
CCAR: 109051729(adhfe1) 109079289
IPU: 108280437(adhfe1)
AMEX: 103028398(adhfe1)
TRU: 101064882(adhfe1)
NCC: 104948694(adhfe1)
MZE: 101480322(adhfe1)
OLA: 101169732(adhfe1)
XMA: 102217742(adhfe1)
PRET: 103460479(adhfe1)
CSEM: 103398723(adhfe1)
LCF: 108884927(adhfe1)
HCQ: 109518917(adhfe1)
BPEC: 110170950(adhfe1)
SASA: 106569039(adhfe1)
ELS: 105010261(adhfe1)
SFM: 108937617(adhfe1)
LCM: 102362120(ADHFE1)
CMK: 103180734(adhfe1)
CIN: 100186144
SPU: 575433
APLC: 110987984
DME: Dmel_CG3425(T3dh)
DSI: Dsimw501_GD25134(Dsim_GD25134)
MDE: 101898360
AGA: AgaP_AGAP006646(HOT_ANOGA)
AAG: 5578877
AME: 100577856 552069(T3dh)
BIM: 100746095
BTER: 100643126
SOC: 105196343
AEC: 105145091
PBAR: 105428988
HST: 105187748
CFO: 105250598
PGC: 109863800
TCA: 656628
NVL: 108561553
PMAC: 106714366
PRAP: 110994911
PXY: 105398318
API: 100169201
DNX: 107163655
ZNE: 110835399
CEL: CELE_Y38F1A.6(hphd-1)
CBR: CBG02769
CRG: 105344644
MYI: 110443496
OBI: 106876888
EPA: 110247393
AQU: 100639220
SLB: AWJ20_1841(ADH4)
NCR: NCU04078
NTE: NEUTE1DRAFT87713(NEUTE1DRAFT_87713)
MGR: MGG_03824
MAW: MAC_03394
MAJ: MAA_01994
CMT: CCM_00356
MBE: MBM_06376
ANI: AN1868.2
ANG: ANI_1_430094(An11g03110)
ABE: ARB_07890
TVE: TRV_00952
PTE: PTT_05756
CNE: CNA01850
CNB: CNBA1780
ABP: AGABI1DRAFT113486(AGABI1DRAFT_113486) AGABI1DRAFT61606(AGABI1DRAFT_61606)
ABV: AGABI2DRAFT191865(AGABI2DRAFT_191865) AGABI2DRAFT229861(AGABI2DRAFT_229861)
DDI: DDB_G0290111(adhfe1)
DFA: DFA_01599(adhfe1)
SPAR: SPRG_14119
STI: Sthe_2689
FMR: Fuma_05697(mdh_2)
ABAC: LuPra_02437(mdh_1)
LOKI: Lokiarch_22120(mdh_2)
 » show all
Taxonomy
Reference
1  [PMID:3182820]
  Authors
Kaufman EE, Nelson T, Fales HM, Levin DM.
  Title
Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria.
  Journal
J. Biol. Chem. 263 (1988) 16872-9.
  Sequence
[rno:362474]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.24
IUBMB Enzyme Nomenclature: 1.1.99.24
ExPASy - ENZYME nomenclature database: 1.1.99.24
BRENDA, the Enzyme Database: 1.1.99.24
CAS: 117698-31-4

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