(R)-pantolactone dehydrogenase (flavin);
2-dehydropantolactone reductase (flavin);
2-dehydropantoyl-lactone reductase (flavin);
(R)-pantoyllactone dehydrogenase (flavin)

Oxidoreductases;
Acting on the CH-OH group of donors;
With other acceptors

(R)-pantolactone:acceptor oxidoreductase (flavin-containing)

(R)-pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor [RN:R03156]

R03156

(R)-pantolactone [CPD:C01012];
acceptor [CPD:C00028]

High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.

1  [PMID:1541293]

Kataoka M, Shimizu S, Yamada H.

Purification and characterization of a novel FMN-dependent enzyme. Membrane-bound L-(+)-pantoyl lactone dehydrogenase from Nocardia asteroides.

Eur. J. Biochem. 204 (1992) 799-806.

Nocardia asteroides