KEGG   ENZYME: 1.1.99.27Help
Entry
EC 1.1.99.27                Enzyme                                 

Name
(R)-pantolactone dehydrogenase (flavin);
2-dehydropantolactone reductase (flavin);
2-dehydropantoyl-lactone reductase (flavin);
(R)-pantoyllactone dehydrogenase (flavin)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
(R)-pantolactone:acceptor oxidoreductase (flavin-containing)
Reaction(IUBMB)
(R)-pantolactone + acceptor = 2-dehydropantolactone + reduced acceptor [RN:R03156]
Reaction(KEGG)
Substrate
(R)-pantolactone [CPD:C01012];
acceptor [CPD:C00028]
Product
2-dehydropantolactone [CPD:C01125];
reduced acceptor [CPD:C00030]
Comment
High specificity for (R)-pantolactone. Phenazine methosulfate (PMS) can act as acceptor. The enzyme has been studied in the bacterium Nocardia asteroides and shown to be membrane-bound and induced by 1,2-propanediol. The FMN cofactor is non-covalently bound.
History
EC 1.1.99.27 created 1999
Reference
1  [PMID:1541293]
  Authors
Kataoka M, Shimizu S, Yamada H.
  Title
Purification and characterization of a novel FMN-dependent enzyme. Membrane-bound L-(+)-pantoyl lactone dehydrogenase from Nocardia asteroides.
  Journal
Eur. J. Biochem. 204 (1992) 799-806.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
140879-14-7

DBGET integrated database retrieval system