KEGG   ENZYME: 1.1.99.3Help
Entry
EC 1.1.99.3                 Enzyme                                 
Name
gluconate 2-dehydrogenase (acceptor);
gluconate oxidase;
gluconate dehydrogenase;
gluconic dehydrogenase;
D-gluconate dehydrogenase;
gluconic acid dehydrogenase;
2-ketogluconate reductase;
D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding;
D-gluconate:(acceptor) 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other acceptors
BRITE hierarchy
Sysname
D-gluconate:acceptor 2-oxidoreductase
Reaction(IUBMB)
D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor [RN:R01742]
Reaction(KEGG)
Substrate
D-gluconate [CPD:C00257];
acceptor [CPD:C00028]
Product
2-dehydro-D-gluconate [CPD:C06473];
reduced acceptor [CPD:C00030]
Comment
A flavoprotein (FAD).
Pathway
Pentose phosphate pathway
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K06151  
gluconate 2-dehydrogenase alpha chain
K06152  
gluconate 2-dehydrogenase gamma chain
Genes
EBT: 
ETA: 
EPY: 
EPR: 
EAM: 
EAY: 
EBI: 
ERJ: 
EAE: 
EAR: 
KPN: 
KPN_02083 KPN_02084
KPU: 
KP1_3158 KP1_3160
KPM: 
KPHS_30620 KPHS_30630
KPP: 
A79E_2171 A79E_2172
KPE: 
KPK_2249 KPK_2250
KPO: 
KPN2242_13365 KPN2242_13370
KVA: 
Kvar_2191 Kvar_2192
CRO: 
ROD_10551 ROD_10561
SPE: 
Spro_2015 Spro_2016 Spro_2136 Spro_2137
SRR: 
SerAS9_2076 SerAS9_2077
SRS: 
SerAS12_2076 SerAS12_2077
SRA: 
SerAS13_2077 SerAS13_2078
SMAF: 
D781_1963 D781_1964 D781_4176 D781_4177
SMW: 
SMWW4_v1c21610 SMWW4_v1c21620
PAM: 
PANA_0300 PANA_0301
PLF: 
PANA5342_4112 PANA5342_4113
PAJ: 
PAJ_3461 PAJ_3462
PAQ: 
PAGR_g3973 PAGR_g3974
PVA: 
Pvag_3559 Pvag_3560 Pvag_3737 Pvag_3738
PAO: 
Pat9b_0347 Pat9b_0348 Pat9b_0543 Pat9b_0544 Pat9b_4596 Pat9b_5244 Pat9b_5245 Pat9b_5797 Pat9b_5798 Pat9b_5874 Pat9b_5875
RAH: 
Rahaq_2101 Rahaq_2102 Rahaq_4655 Rahaq_4656
RAQ: 
Rahaq2_2467 Rahaq2_2468 Rahaq2_4651 Rahaq2_4652
RAA: 
Q7S_10650 Q7S_10655 Q7S_23796 Q7S_23801
ROR: 
RORB6_04520 RORB6_04525
EBF: 
D782_2836 D782_2837
FAU: 
Fraau_0057 Fraau_0058
PAE: 
PA2264 PA2265
PAU: 
PA14_35290(gnd) PA14_35300
PAP: 
PSPA7_2975 PSPA7_2976
PAG: 
PLES_30391 PLES_30401
PAF: 
PAM18_2775 PAM18_2776
PNC: 
NCGM2_3274 NCGM2_3275(gnd)
PDK: 
PADK2_13950 PADK2_13955
PSG: 
G655_13715 G655_13720
PPU: 
PP_3383 PP_3384
PPF: 
Pput_2375 Pput_2376
PPG: 
PputGB1_2561 PputGB1_2562
PPW: 
PputW619_2564 PputW619_2565
PPT: 
PPS_2860 PPS_2861
PPB: 
PPUBIRD1_2397 PPUBIRD1_2398
PPI: 
YSA_11149 YSA_11151
PPX: 
T1E_5154 T1E_5155
PPUH: 
B479_14220 B479_14225
PFL: 
PFL_0053 PFL_0054
PFO: 
Pfl01_0085 Pfl01_0086
PFS: 
PFLU0051 PFLU0052
PFC: 
PflA506_0050 PflA506_0051
PPZ: 
H045_21365 H045_21370
PFV: 
Psefu_0559 Psefu_0560
AVN: 
Avin_00890(gadh3) Avin_00900(gadh1)
AVL: 
AvCA_00890(gadh3) AvCA_00900(gadh1) AvCA_33650 AvCA_33660
AVD: 
AvCA6_00890(gadh3) AvCA6_00900(gadh1) AvCA6_33650 AvCA6_33660
SWD: 
Swoo_3000
TVI: 
Thivi_4496
HEL: 
HELO_3277(gnd) HELO_3279
RME: 
Rmet_2503 Rmet_2504
BVI: 
Bcep1808_4793 Bcep1808_4794
BUR: 
Bcep18194_B1793 Bcep18194_B1794
BCN: 
Bcen_4142 Bcen_4143
BCH: 
Bcen2424_4223 Bcen2424_4224
BCM: 
Bcenmc03_3293 Bcenmc03_3294
BCJ: 
BCAM1356 BCAM1357
BAM: 
Bamb_3645 Bamb_3646
BAC: 
BamMC406_4119 BamMC406_4120
BMU: 
Bmul_4381 Bmul_4382
BMJ: 
BMULJ_04124 BMULJ_04125
BCT: 
GEM_2222 GEM_4396 GEM_4397
BXE: 
Bxe_A4094 Bxe_A4095 Bxe_C0229 Bxe_C0230
BPY: 
Bphyt_0228 Bphyt_4639 Bphyt_4640 Bphyt_6209 Bphyt_6210
BGF: 
BC1003_5032 BC1003_5033
BGD: 
bgla_2g10400
BUK: 
MYA_4428 MYA_4429
BPA: 
BPP2079 BPP2080
BPAR: 
BN117_1232 BN117_1233
BBR: 
BB1475 BB1476
BBM: 
BN115_1430 BN115_1431
BBH: 
BN112_1984 BN112_1985
BPT: 
Bpet3834 Bpet3835
BAV: 
BAV3248 BAV3249
AXY: 
AXYL_03688 AXYL_03689
VEI: 
Veis_1597 Veis_1598
VAP: 
Vapar_5398 Vapar_5399
CTT: 
CtCNB1_2719 CtCNB1_2720
RTA: 
Rta_06280 Rta_06290 Rta_11590 Rta_11600
HSE: 
Hsero_3342(betA) Hsero_3343 Hsero_4479 Hsero_4563
CJE: 
Cj0414 Cj0415
CJB: 
BN148_0414 BN148_0415
CJJ: 
CJJ81176_0438 CJJ81176_0439
CJU: 
C8J_0142 C8J_0389 C8J_0390
CJN: 
ICDCCJ_378 ICDCCJ_379
CJI: 
CJSA_0387 CJSA_0388
CJM: 
CJM1_0148 CJM1_0392 CJM1_0393
CJS: 
CJS3_0404 CJS3_0405
CJP: 
A911_02015 A911_02020
CJR: 
CJE0463 CJE0464
MXA: 
MXAN_1341
MFU: 
LILAB_02105
MSD: 
MYSTI_01347
CCX: 
COCOR_01230
SUR: 
STAUR_2062
MCI: 
Mesci_4079 Mesci_4080
MAM: 
Mesau_01344 Mesau_01345
SMQ: 
SinmeB_5878 SinmeB_5879
RHI: 
NGR_b01110 NGR_b01120 NGR_b01130
OAN: 
Oant_3608 Oant_3609
BJU: 
BJ6T_45940 BJ6T_45950
NHA: 
Nham_4243 Nham_4244
AOL: 
S58_52020 S58_52030
AZC: 
AZC_2718 AZC_2719
MPO: 
Mpop_4202 Mpop_4203
DSH: 
Dshi_3895 Dshi_3896
KVU: 
EIO_0520 EIO_0521
GOX: 
GOX1231 GOX1232
GOH: 
B932_0899 B932_0900
GDI: 
GDI_0854 GDI_0855
GDJ: 
Gdia_1164 Gdia_1165
GXY: 
GLX_11310 GLX_11320
ALI: 
AZOLI_p20467 AZOLI_p20468
TMO: 
TMO_c0268 TMO_c0269
LSP: 
Bsph_0678 Bsph_0679
BBE: 
BBR47_55430 BBR47_55440
PJD: 
Pjdr2_2941 Pjdr2_2942
GYM: 
GYMC10_2887 GYMC10_2888
ASD: 
AS9A_2241 AS9A_2242
ART: 
Arth_1924
APN: 
Asphe3_34760
VMA: 
VAB18032_16575
SUS: 
Acid_5750 Acid_5751
OTE: 
Oter_2178
DGO: 
DGo_PB0074 DGo_PB0075
TTS: 
Ththe16_2119 Ththe16_2120
HTU: 
Htur_1314
HXA: 
Halxa_3870
HRU: 
Halru_0456
NOU: 
Natoc_2870 Natoc_2871
 » show all
Taxonomy
Reference
1  [PMID:6815420]
  Authors
Matsushita K, Shinagawa E, Ameyama M.
  Title
D-Gluconate dehydrogenase from bacteria, 2-keto-D-gluconate-yielding, membrane-bound.
  Journal
Methods. Enzymol. 89 Pt D (1982) 187-93.
  Organism
Klebsiella pneumoniae, Pseudomonas aeruginosa, Pseudomonas fluorescens, Serratia marcescens
Reference
2  [PMID:13239635]
  Authors
RAMAKRISHNAN T, CAMPBELL JJ.
  Title
Gluconic dehydrogenase of Pseudomonas aeruginosa.
  Journal
Biochim. Biophys. Acta. 17 (1955) 122-7.
  Organism
Pseudomonas aeruginosa
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-81-3
DBGET integrated database retrieval system