KEGG   ENZYME: 1.1.99.30Help
Entry
EC 1.1.99.30                Enzyme                                 

Name
2-oxo-acid reductase;
(2R)-hydroxycarboxylate-viologen-oxidoreductase;
HVOR;
2-oxoacid reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other, unknown, acceptors
BRITE hierarchy
Sysname
(2R)-hydroxy-carboxylate:acceptor oxidoreductase
Reaction(IUBMB)
a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor [RN:R07155]
Reaction(KEGG)
Substrate
(R)-2-hydroxycarboxylate [CPD:C02489];
acceptor [CPD:C00028]
Product
2-oxocarboxylate [CPD:C00161];
reduced acceptor [CPD:C00030]
Comment
Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen.
History
EC 1.1.99.30 created 2004
Reference
1  [PMID:8026480]
  Authors
Trautwein T, Krauss F, Lottspeich F, Simon H.
  Title
The (2R)-hydroxycarboxylate-viologen-oxidoreductase from Proteus vulgaris is a molybdenum-containing iron-sulphur protein.
  Journal
Eur. J. Biochem. 222 (1994) 1025-32.
  Sequence
[up:Q9R4Y1]
Reference
2
  Authors
Neumann, S. and Simon, H.
  Title
On a non-pyridine nucleotide-dependent 2-oxoacid reductase of broad specificity from two Proteus species.
  Journal
FEBS Lett. 167 (1985) 29-32.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
115299-99-5

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